Polyhydroxy steroids isolated from starfish (Asterina pectinifera) and their embryotoxicity
文献类型：期刊论文
| 作者 | Zhang, Ranran3,4; Lu, Zhen4; Wang, Derui2,4; Yan, Zhi1,4; Sun, Xueting4; Li, Xiaodong4; Yin, Xiuli4 ; Li, Ke4
|
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2024-05-02 |
| 页码 | 7 |
| 关键词 | Polyhydroxy steroids embryotoxicity starfish Asterina pectinifera |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2024.2350639 |
| 通讯作者 | Li, Ke(kli@yic.ac.cn) |
| 英文摘要 | Many marine organisms possess an essential capacity to produce secondary metabolites that exhibit toxic characteristics. A new polyhydroxy steroid, 24-methyl-5 alpha-cholestane-24(28)-ene-3 beta, 4 beta, 6 alpha, 7 alpha, 8, 15 beta, 16 beta, 26-octol-6-O-sodium sulphate (1) was isolated from starfish (Asterina pectinifera), along with five polar steroid compounds (2-6) that were previously identified. NMR (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, HMBC, and NOESY) and HR-ESI-MS were employed for structure elucidations. The embryotoxicity and teratogenicity of the isolated compounds were assessed using embryos of marine medaka (Oryzias melastigma). Compound 5 exhibited moderate embryotoxicity (96h-LC50: 65 mu M). [Graphical Abstract] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001219554600001 |
| 资助机构 | National Natural Science Foundation of China ; Taishan Scholar Program from Shandong Province of China ; Shuangbai Plan ; Yantai Municipal City's |
| 源URL | [http://ir.yic.ac.cn/handle/133337/36056]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Li, Ke |
| 作者单位 | 1.Yantai Univ, Sch Ocean, Yantai, Peoples R China 2.Beibu Gulf Univ, Coll Marine Sci, Qinzhou, Peoples R China 3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ranran,Lu, Zhen,Wang, Derui,et al. Polyhydroxy steroids isolated from starfish (Asterina pectinifera) and their embryotoxicity[J]. NATURAL PRODUCT RESEARCH,2024:7. |
| APA | Zhang, Ranran.,Lu, Zhen.,Wang, Derui.,Yan, Zhi.,Sun, Xueting.,...&Li, Ke.(2024).Polyhydroxy steroids isolated from starfish (Asterina pectinifera) and their embryotoxicity.NATURAL PRODUCT RESEARCH,7. |
| MLA | Zhang, Ranran,et al."Polyhydroxy steroids isolated from starfish (Asterina pectinifera) and their embryotoxicity".NATURAL PRODUCT RESEARCH (2024):7. |
入库方式： OAI收割
来源：烟台海岸带研究所
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