Advances in peptide-based drug delivery systems
文献类型：期刊论文
| 作者 | Guo, Sijie1,2; Wang, Jing1; Wang, Qi1,2; Wang, Jinxin3; Qin, Song1 ; Li, Wenjun1,2
|
| 刊名 | HELIYON
 |
| 出版日期 | 2024-02-29 |
| 卷号 | 10期号:4页码:21 |
| 关键词 | Functional peptide Drug delivery system Peptide -drug coupling Application prospects |
| DOI | 10.1016/j.heliyon.2024.e26009 |
| 通讯作者 | Li, Wenjun(wjli@yic.ac.cn) |
| 英文摘要 | Drug delivery systems (DDSs) are designed to deliver drugs to their specific targets to minimize their toxic effects and improve their susceptibility to clearance during targeted transport. Peptides have high affinity, low immunogenicity, simple amino acid composition, and adjustable molecular size; therefore, most peptides can be coupled to drugs via linkers to form peptide-drug conjugates (PDCs) and act as active pro-drugs. PDCs are widely thought to be promising DDSs, given their ability to improve drug bio-compatibility and physiological stability. Peptide-based DDSs are often used to deliver therapeutic substances such as anti-cancer drugs and nucleic acid-based drugs, which not only slow the degradation rate of drugs in vivo but also ensure the drug concentration at the targeted site and prolong the half-life of drugs in vivo. This article provides an profile of the advancements and future development in functional peptide-based DDSs both domestically and internationally in recent years, in the expectation of achieving targeted drug delivery incorporating functional peptides and taking full advantage of synergistic effects. |
| WOS关键词 | CELL-PENETRATING PEPTIDES ; TUMOR-ASSOCIATED MACROPHAGES ; HOMING PEPTIDES ; POLYPEPTIDE NANOPARTICLES ; TARGETED DELIVERY ; CANCER-THERAPY ; PLASMID DNA ; IN-SITU ; MICROENVIRONMENT ; OVARIAN |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001198253500001 |
| 资助机构 | National Key Research and Development Program of China ; Jilin Province ; Chinese Academy of Sciences ; Special Plan for Major Scientific and Technological Innovation in Qingdao West Coast |
| 源URL | [http://ir.yic.ac.cn/handle/133337/36114]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 通讯作者 | Li, Wenjun |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 2.Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao 266112, Shandong, Peoples R China 3.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Sijie,Wang, Jing,Wang, Qi,et al. Advances in peptide-based drug delivery systems[J]. HELIYON,2024,10(4):21. |
| APA | Guo, Sijie,Wang, Jing,Wang, Qi,Wang, Jinxin,Qin, Song,&Li, Wenjun.(2024).Advances in peptide-based drug delivery systems.HELIYON,10(4),21. |
| MLA | Guo, Sijie,et al."Advances in peptide-based drug delivery systems".HELIYON 10.4(2024):21. |
入库方式： OAI收割
来源：烟台海岸带研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。