Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases
文献类型：期刊论文
| 作者 | Li, Lili1,7 ; Wang, Ping1,7; Jiao, Xudong1; Qin, Song1; Liu, Zhengyi1; Ye, Yanrui6; Song, Yipeng2,5; Hou, Hu3,4
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| 刊名 | OBESITY REVIEWS
 |
| 出版日期 | 2024-03-10 |
| 页码 | 11 |
| 关键词 | adipose tissue diabetes fatty acid esters of hydroxy fatty acids inflammation structure-activity relationship |
| ISSN号 | 1467-7881 |
| DOI | 10.1111/obr.13735 |
| 通讯作者 | Song, Yipeng(syp1972@sina.com) ; Hou, Hu(houhu@ouc.edu.cn) |
| 英文摘要 | Obesity, a burgeoning worldwide health system challenge, is associated with multiple chronic diseases, including diabetes and chronic inflammation. Fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified lipids with mitigating and anti-inflammatory effects in diabetes. Increasing work has shown that FAHFAs exert antioxidant activity and enhance autophagy in neuronal cells and cardiomyocytes. We systematically summarized the biological activities of FAHFAs, including their regulatory effects on diabetes and inflammation, antioxidant activity, and autophagy augmentation. Notably, the structure-activity relationships and potential biosynthesis of FAHFAs are thoroughly discussed. FAHFAs also showed potential roles as diagnostic biomarkers. FAHFAs are a class of resources with promising applications in the biomedical field that require in-depth research and hotspot development, as their structure has not been fully resolved and their biological activity has not been fully revealed. |
| WOS关键词 | DE-NOVO LIPOGENESIS ; INSULIN-RESISTANCE ; ENERGY-METABOLISM ; OXIDATIVE STRESS ; GLUCOSE ; ADIPOCYTES ; FAHFAS ; GPR40 ; INFLAMMATION ; LIPIDOMICS |
| WOS研究方向 | Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:001181626800001 |
| 资助机构 | National Key Research and Development Program |
| 源URL | [http://ir.yic.ac.cn/handle/133337/36286]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 通讯作者 | Song, Yipeng; Hou, Hu |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 2.Yantai Yuhuangding Hosp, 20 Yudong Rd, Yantai 264000, Shandong, Peoples R China 3.Ocean Univ China, Qingdao, Peoples R China 4.Ocean Univ China, 5 Yushan Rd, Qingdao 266003, Shandong, Peoples R China 5.Yantai Yuhuangding Hosp, Yantai, Peoples R China 6.South China Univ Technol, Sch Biol & Biol Engn, Guangzhou, Peoples R China 7.Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Lili,Wang, Ping,Jiao, Xudong,et al. Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases[J]. OBESITY REVIEWS,2024:11. |
| APA | Li, Lili.,Wang, Ping.,Jiao, Xudong.,Qin, Song.,Liu, Zhengyi.,...&Hou, Hu.(2024).Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases.OBESITY REVIEWS,11. |
| MLA | Li, Lili,et al."Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases".OBESITY REVIEWS (2024):11. |
入库方式： OAI收割
来源：烟台海岸带研究所
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