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CsIL-20, a tongue sole interleukin-20, negatively mediates leucocyte activity and antibacterial defense

文献类型：期刊论文

作者Zhao, Kun-yu4; Huang, Hui5; Jin, Qiu4; Jiao, Xu-dong1,3; Li, Xue-peng2,4
刊名FISH & SHELLFISH IMMUNOLOGY
出版日期2024-02-01
卷号145页码:9
关键词Interleukin-20 Cynoglossus semilaevis Expression patterns PBLs activity Antibacterial immunity
ISSN号1050-4648
DOI10.1016/j.fsi.2023.109325
通讯作者Jiao, Xu-dong(xdjiao@yic.ac.cn) ; Li, Xue-peng(lixuepeng14@mails.ucas.ac.cn)
英文摘要Interleukin-20 (IL-20), as an essential member of IL-10 family, plays vital roles in mammalian immunological response such as antimicrobial, inflammation, hematopoiesis, and immune diseases. In teleost, the study about immune antimicrobial function of IL-20 is largely scarce. In this article, we revealed the expression profiles and the immunological functions of the IL-20 (CsIL-20) in tongue sole Cynoglossus semilaevis. CsIL-20 is composed of 183 amino acid residues, with seven cysteine residues and a typical IL-10 domain which comprises six alpha-helices and two 13-sheets, and shares 34.4-71.2 % identities with other teleost IL-20. CsIL-20 was constitutively expressed in a variety of tissues and regulated by bacterial invasion, and the recombinant CsIL-20 (rCsIL-20) could bind to different bacteria. In vitro rCsIL-20 could interact with the membrane of peripheral blood leukocytes (PBLs), leading to the attenuation of reactive oxygen species (ROS) production and acid phosphatase activity in PBLs. In line with In vitro results, In vivo rCsIL-20 could obviously suppressed the host immune against bacterial infection. Furthermore, knockdown of CsIL-20 in vivo could markedly enhance the host antibacterial immunity. Collectively, these observations offer new insights into the negative effect of CsIL-20 on antibacterial immunity.
WOS关键词BACTERIAL-INFECTION ; RECEPTOR COMPLEXES ; IL-20 SUBFAMILY ; IL-10 FAMILY ; IN-VITRO ; CYTOKINES ; ACTIVATION ; IL-1-BETA ; IMMUNITY ; PATHWAY
WOS研究方向Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种英语
WOS记录号WOS:001154541100001
资助机构Development Plan of Youth Innovation Team in Colleges and Universities of Shandong Province ; Yantai Key Laboratory of Quality and Safety Control and Deep Processing of Marine Food ; Shandong Provincial Modern Agricultural Industry Technology System
源URL[http://ir.yic.ac.cn/handle/133337/36354]  
专题海岸带生物学与生物资源利用重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
通讯作者Jiao, Xu-dong; Li, Xue-peng
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resource Utilizat, Yantai, Peoples R China
2.Yantai Univ, 30 Qingquan Rd, Yantai 264005, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, 17 Chunhui Rd, Yantai 264003, Peoples R China
4.Yantai Univ, Sch Ocean, Yantai, Peoples R China
5.Shandong Marine Resource & Environm Res Inst, Yantai, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Kun-yu,Huang, Hui,Jin, Qiu,et al. CsIL-20, a tongue sole interleukin-20, negatively mediates leucocyte activity and antibacterial defense[J]. FISH & SHELLFISH IMMUNOLOGY,2024,145:9.
APA Zhao, Kun-yu,Huang, Hui,Jin, Qiu,Jiao, Xu-dong,&Li, Xue-peng.(2024).CsIL-20, a tongue sole interleukin-20, negatively mediates leucocyte activity and antibacterial defense.FISH & SHELLFISH IMMUNOLOGY,145,9.
MLA Zhao, Kun-yu,et al."CsIL-20, a tongue sole interleukin-20, negatively mediates leucocyte activity and antibacterial defense".FISH & SHELLFISH IMMUNOLOGY 145(2024):9.

入库方式： OAI收割

来源：烟台海岸带研究所

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