Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle
文献类型：期刊论文
| 作者 | Yuan, Yuting1,2,3; Tan, Wenqiang1,2 ; Mi, Yingqi1,2; Wang, Linqing1,2,3; Qi, Zhen4; Guo, Zhanyong1,2,3
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2024 |
| 卷号 | 22期号:1页码:18 |
| 关键词 | different hydrophobic chain length low molecular weight chitosan trigger-release |
| DOI | 10.3390/md22010018 |
| 通讯作者 | Tan, Wenqiang(wqtan@yic.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com) |
| 英文摘要 | Three redox-sensitive nanocarriers were rationally designed based on amphiphilic low molecular weight chitosan-cystamine-octylamine/dodecylamin/cetylamine (LC-Cys-OA, LC-Cys-DA, LC-Cys-CA) conjugates containing disulfide linkage for maximizing therapeutic effect by regulating hydrophobic interaction. The resultant spherical micelles had the characteristics of low CMC, suitable size, excellent biosafety and desired stability. The drug-loaded micelles were fabricated by embedding doxorubicin (Dox) into the hydrophobic cores. The effect of hydrophobic chain lengths of amphiphilic conjugates on encapsulation capacity, redox sensitivity, trigger-release behavior, cellular uptake efficacy, antitumor effect and antimigratory activity of Dox-loaded micelles was systematically investigated. Studies found that Dox-loaded LC-Cys-CA micelle had superior loading capacity and enhanced redox sensitivity compared with the other two micelles. Release assay indicated that the three Dox-loaded micelles maintained sufficiently stability in normal blood circulation but rapidly disintegrated in tumor cells. More importantly, the LC-Cys-CA micelle with a longer hydrophobic chain length exhibited a higher accumulative Dox release percentage than the other two micelles. Additionally, an increase in hydrophobic chain lengths of amphiphilic conjugates improved cellular uptake efficiency, antitumor effect and antimigration activity of Dox-loaded micelles, which could be explained by enhanced loading ability and redox sensitivity. Our research was expected to provide a viable platform for achieving a desired therapeutic efficacy via the alteration of hydrophobic interaction. |
| WOS关键词 | POLYMERIC MICELLES ; BLOCK-COPOLYMERS ; ANTICANCER DRUG ; SENSITIVE MICELLES ; MIXED MICELLES ; CO-DELIVERY ; CANCER ; DOCETAXEL |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001150853800001 |
| 资助机构 | Youth Innovation Promotion Association CAS |
| 源URL | [http://ir.yic.ac.cn/handle/133337/36378]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Tan, Wenqiang; Guo, Zhanyong |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Yuting,Tan, Wenqiang,Mi, Yingqi,et al. Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle[J]. MARINE DRUGS,2024,22(1):18. |
| APA | Yuan, Yuting,Tan, Wenqiang,Mi, Yingqi,Wang, Linqing,Qi, Zhen,&Guo, Zhanyong.(2024).Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle.MARINE DRUGS,22(1),18. |
| MLA | Yuan, Yuting,et al."Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle".MARINE DRUGS 22.1(2024):18. |
入库方式： OAI收割
来源：烟台海岸带研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。