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  4. 中科院海岸带环境过程与生态修复重点实验室
NIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy

文献类型：期刊论文

作者Fu, Lili1,3; Huang, Yan1; Shan, Xin4; Sun, Xiao1; Wang, Xinlei1; Wang, Xiaoyan1; Chen, Lingxin1,2; Yu, Shui1
刊名JOURNAL OF NANOBIOTECHNOLOGY
出版日期2024-10-01
卷号22期号:1页码:15
关键词Photodynamic therapy Nanoplatforms Mesoporous silica materials Small-molecule photosensitizers Nitric oxide release
DOI10.1186/s12951-024-02878-7
通讯作者Huang, Yan(yhuang@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn) ; Yu, Shui(yushui_0121@163.com)
英文摘要BackgroundTherapeutic approaches that combine conventional photodynamic therapy (PDT) with gas therapy (GT) to sensitize PDT are an attractive strategy, but the molecular structure design of the complex lacks effective guiding strategies.ResultsHerein, we have developed a nanoplatforms Cy-NMNO@SiO2 based on mesoporous silica materials loaded NIR-activatable small-molecule fluorescent probe Cy-NMNO for the synergistic treatment of photodynamic therapy/gas therapy (PDT/GT) in antibacterial and skin cancer. The theoretical calculation results showed that the low dissociation of N-NO in Cy-NMNO enabled it to dissociate effectively under NIR light irradiation, which is conducive to produce Cy and NO. Cy showed better 1O2 generation performance than Cy-NMNO. The cytotoxicity of Cy-NMNO obtained via the synergistic effect of GT and PDT synergistically enhances the effect of photodynamic therapy, thus achieving more effective tumor treatment and sterilization than conventional PDT. Moreover, the nanoplatforms Cy-NMNO@SiO2 realized efficient drug loading and drug delivery.ConclusionsThis work not only offers a promising approach for PDT-GT synergistic drug delivery system, but also provides a valuable reference for the design of its drug molecules.
WOS关键词MESOPOROUS SILICA NANOPARTICLES ; HYPOXIA ; HIF-1
WOS研究方向Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
语种英语
WOS记录号WOS:001326709800001
资助机构National Natural Science Foundation of China
源URL[http://ir.yic.ac.cn/handle/133337/36524]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Huang, Yan; Chen, Lingxin; Yu, Shui
作者单位1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
3.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Shandong, Peoples R China
4.Shandong City Serv Inst, Dept Intelligent Mfg, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Fu, Lili,Huang, Yan,Shan, Xin,et al. NIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy[J]. JOURNAL OF NANOBIOTECHNOLOGY,2024,22(1):15.
APA Fu, Lili.,Huang, Yan.,Shan, Xin.,Sun, Xiao.,Wang, Xinlei.,...&Yu, Shui.(2024).NIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy.JOURNAL OF NANOBIOTECHNOLOGY,22(1),15.
MLA Fu, Lili,et al."NIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy".JOURNAL OF NANOBIOTECHNOLOGY 22.1(2024):15.

入库方式： OAI收割

来源：烟台海岸带研究所

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