Ginkgo biloba for Tardive Dyskinesia and Plasma MnSOD Activity: Association with MnSOD Ala-9Val Variant: A Randomized, Double-blind Trial
文献类型：期刊论文
| 作者 | Wang, Dongmei3,4 ; Tian, Yang3,4; Chen, Jiajing3,4; Zhu, Rongrong3,4; Li, Jiaxin3,4; Zhou, Huixia3,4; Chen, Dachun2; Wang, Li3,4; Kosten, Thomas R.1; Zhang, Xiang-Yang3,4
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| 刊名 | CURRENT NEUROPHARMACOLOGY
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| 出版日期 | 2024 |
| 卷号 | 22期号:14页码:2443-2452 |
| 关键词 | Schizophrenia genotype pharmacogenetics ginkgo biloba extract tardive dyskinesia plasma MnSOD |
| ISSN号 | 1570-159X |
| DOI | 10.2174/1570159X22666240530095721 |
| 通讯作者 | Zhang, Xiang-Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Background Excessive free radicals are implicated in the pathophysiology of tardive dyskinesia (TD), and Ginkgo biloba extract (EGb761) scavenges free radicals, thereby enhancing antioxidant enzymes such as mitochondrial manganese superoxide dismutase (MnSOD). This study examined whether EGb761 treatment would improve TD symptoms and increase MnSOD activity, particularly in TD patients with specific MnSOD Val-9Ala genotype. Methods An EGb761 (240 mg/day) 12-week double-blind clinical trial with 157 TD patients was randomized. The severity of TD was measured by the Abnormal Involuntary Movement Scale (AIMS) and plasma MnSOD activity was assayed before and after 12 weeks of treatment. Further, in an expanded sample, we compared MnSOD activity in 159 TD, 227 non-TD and 280 healthy controls, as well as the allele frequencies and genotypes for the MnSOD Ala-9Val polymorphism in 352 TD, 486 non-TD and 1150 healthy controls. Results EGb761 significantly reduced TD symptoms and increased MnSOD activity in TD patients compared to placebo (both p < 0.01). Moreover, we found an interaction between genotype and treatment response (p < 0.001). Furthermore, in the EGb761 group, patients carrying the Ala allele displayed a significantly lower AIMS total score than patients with the Val/Val genotype. In addition, MnSOD activity was significantly lower at baseline in TD patients compared with healthy controls or non-TD patients. Conclusion EGb761 treatment enhanced low MnSOD activity in TD patients and produced greater improvement in TD symptoms in patients with the Ala allele of the MnSOD Ala-9Val polymorphism. Clinical Trial Registration No NCT00672373. |
| 收录类别 | SCI |
| WOS关键词 | MANGANESE SUPEROXIDE-DISMUTASE ; ABNORMAL INVOLUNTARY MOVEMENTS ; OXIDATIVE STRESS ; ANTIOXIDANT DEFENSE ; DISORDERS SADIMOD ; GENE POLYMORPHISM ; DOPAMINE D3 ; SCHIZOPHRENIA ; EXTRACT ; SUSCEPTIBILITY |
| 资助项目 | National Natural Science Foundation of China[31300848] ; STI2030-Major projects[2021ZD0202102] ; CAS International Cooperation Research Program[153111KYSB20190004] |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001319473600007 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 资助机构 | National Natural Science Foundation of China ; STI2030-Major projects ; CAS International Cooperation Research Program |
| 源URL | [http://ir.psych.ac.cn/handle/311026/49043]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiang-Yang |
| 作者单位 | 1.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX USA 2.Beijing HuiLongGuan Hosp, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Dongmei,Tian, Yang,Chen, Jiajing,et al. Ginkgo biloba for Tardive Dyskinesia and Plasma MnSOD Activity: Association with MnSOD Ala-9Val Variant: A Randomized, Double-blind Trial[J]. CURRENT NEUROPHARMACOLOGY,2024,22(14):2443-2452. |
| APA | Wang, Dongmei.,Tian, Yang.,Chen, Jiajing.,Zhu, Rongrong.,Li, Jiaxin.,...&Zhang, Xiang-Yang.(2024).Ginkgo biloba for Tardive Dyskinesia and Plasma MnSOD Activity: Association with MnSOD Ala-9Val Variant: A Randomized, Double-blind Trial.CURRENT NEUROPHARMACOLOGY,22(14),2443-2452. |
| MLA | Wang, Dongmei,et al."Ginkgo biloba for Tardive Dyskinesia and Plasma MnSOD Activity: Association with MnSOD Ala-9Val Variant: A Randomized, Double-blind Trial".CURRENT NEUROPHARMACOLOGY 22.14(2024):2443-2452. |
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来源：心理研究所
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