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The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study

文献类型：期刊论文

作者Kong, Li8; Zhang, Yao6,7; Wu, Xu-ming5; Wang, Xiao-xiao6,7; Wu, Hai-su7; Li, Shuai-biao7; Chu, Min-yi7; Wang, Yi3,4; Lui, Simon S. Y.2; Lv, Qin-yu6,7
刊名SCHIZOPHRENIA
出版日期2024-01-17
卷号10期号:1页码:6
DOI10.1038/s41537-023-00408-2
通讯作者Yi, Zheng-hui(yizhenghui1971@163.com)
英文摘要Previous studies on putative neural mechanisms of negative symptoms in schizophrenia mainly used single modal imaging data, and seldom utilized schizophrenia patients with prominent negative symptoms (PNS).This study adopted the multimodal fusion method and recruited a homogeneous sample with PNS. We aimed to identify negative symptoms-related structural and functional neural correlates of schizophrenia. Structural magnetic resonance imaging (sMRI) and resting-state functional MRI (rs-fMRI) were performed in 31 schizophrenia patients with PNS and 33 demographically matched healthy controls.Compared to healthy controls, schizophrenia patients with PNS exhibited significantly altered functional activations in the default mode network (DMN) and had structural gray matter volume (GMV) alterations in the cerebello-thalamo-cortical network. Correlational analyses showed that negative symptoms severity was significantly correlated with the cerebello-thalamo-cortical structural network, but not with the DMN network in schizophrenia patients with PNS.Our findings highlight the important role of the cerebello-thalamo-cortical structural network underpinning the neuropathology of negative symptoms in schizophrenia. Future research should recruit a large sample and schizophrenia patients without PNS, and apply adjustments for multiple comparison, to verify our preliminary findings.
收录类别SCI
WOS关键词MCCA PLUS JICA ; 1ST-EPISODE SCHIZOPHRENIA ; SCHIZOAFFECTIVE DISORDER ; BIPOLAR DISORDER ; WHITE-MATTER ; GRAY-MATTER ; CONNECTIVITY ; FMRI ; ABNORMALITIES ; SUBSYNDROMES
资助项目Natural Science Foundation of China[82071501] ; Shanghai Science and Technology Innovation Action Plan Natural Science Fund Project[21ZR1455400]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001295307900001
出版者NATURE PORTFOLIO
资助机构Natural Science Foundation of China ; Shanghai Science and Technology Innovation Action Plan Natural Science Fund Project
源URL[http://ir.psych.ac.cn/handle/311026/49073]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Yi, Zheng-hui
作者单位1.Fudan Univ, Inst Mental Hlth, Shanghai, Peoples R China
2.Univ Hong Kong, Sch Clin Med, Dept Psychiat, Hong Kong, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Nantong Fourth Peoples Hosp, Nantong, Peoples R China
6.Fudan Univ, Huashan Hosp, Dept Psychiat, Shanghai, Peoples R China
7.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China
8.Shanghai Normal Univ, Dept Psychol, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Kong, Li,Zhang, Yao,Wu, Xu-ming,et al. The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study[J]. SCHIZOPHRENIA,2024,10(1):6.
APA Kong, Li.,Zhang, Yao.,Wu, Xu-ming.,Wang, Xiao-xiao.,Wu, Hai-su.,...&Chan, Raymond C. K..(2024).The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study.SCHIZOPHRENIA,10(1),6.
MLA Kong, Li,et al."The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study".SCHIZOPHRENIA 10.1(2024):6.

入库方式： OAI收割

来源：心理研究所

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