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PM2.5-mediated cardiovascular disease in aging: Cardiometabolic risks, molecular mechanisms and potential interventions

文献类型：期刊论文

作者Chanda, Francis8,9,10; Lin, Kai-xuan6,7; Chaurembo, Abdallah Iddy8,9,10; Huang, Jian-yuan5,10; Zhang, Hui-juan4,10; Deng, Wen-hui5,10; Xu, Yun-jing8,9,10; Li, Yuan6,10; Fu, Li-dan4,10; Cui, Hao-dong3,10
刊名SCIENCE OF THE TOTAL ENVIRONMENT
出版日期2024-12-01
卷号954页码:22
关键词PM2.5 Cardiovascular disease Cardiometabolic risk Older adults Inflammation Oxidative stress Oxidative stress
ISSN号0048-9697
DOI10.1016/j.scitotenv.2024.176255
通讯作者Xing, Na(xingna@zidd.ac.cn) ; Lin, Han-bin(linhanbin@simm.ac.cn)
英文摘要Air pollution, particularly fine particulate matter (PM2.5) with <2.5 mu m in diameter, is a major public health concern. Studies have consistently linked PM2.5 exposure to a heightened risk of cardiovascular diseases (CVDs) such as ischemic heart disease (IHD), heart failure (HF), and cardiac arrhythmias. Notably, individuals with pre-existing age-related cardiometabolic conditions appear more susceptible. However, the specific impact of PM2.5 on CVDs susceptibility in older adults remains unclear. Therefore, this review addresses this gap by discussing the factors that make the elderly more vulnerable to PM2.5-induced CVDs. Accordingly, we focused on physiological aging, increased susceptibility, cardiometabolic risk factors, CVDs, and biological mechanisms. This review concludes by examining potential interventions to reduce exposure and the adverse health effects of PM2.5 in the elderly population. The latter includes dietary modifications, medications, and exploration of the potential benefits of supplements. By comprehensively analyzing these factors, this review aims to provide a deeper understanding of the detrimental effects of PM2.5 on cardiovascular health in older adults. This knowledge can inform future research and guide strategies to protect vulnerable populations from the adverse effects of air pollution.
WOS关键词FINE PARTICULATE MATTER ; LONG-TERM EXPOSURE ; FATTY LIVER-DISEASE ; AIR-POLLUTION ; AMBIENT PM2.5 ; OXIDATIVE STRESS ; SUBCLINICAL ATHEROSCLEROSIS ; PARTICLE EXPOSURE ; BLOOD-PRESSURE ; CAROTID ATHEROSCLEROSIS
资助项目ANSO Scholarship for Young Talent[2022ANSOM122] ; National Natural Science Foundation of China[82100391] ; Guangdong Provincial Pearl River Talents Program[211283781015] ; State key Laboratory of Drug Research of Shanghai Institute of Materia Medica Chinese Academy of Sciences[SKLDR-2024-KF-08] ; High-level New RD Institute[2019B090904008] ; High-level Innovative Research Institute[2021B0909050003] ; Zhongshan Science and Technology Bureau[2023B2031]
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:001321139300001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/313630]  
专题中国科学院上海药物研究所
通讯作者Xing, Na; Lin, Han-bin
作者单位1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Res Ctr Atmospher Environm, Chongqing, Peoples R China
2.Shenyang Agr Univ, Food Sci Coll, Shenyang, Liaoning, Peoples R China
3.Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang, Guizhou, Peoples R China
4.Zunyi Med Univ, Sch Pharm, Zunyi, Guizhou, Peoples R China
5.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China
6.Guangzhou Univ Chinese Med, Guangzhou, Guangdong, Peoples R China
7.Guangzhou Univ Tradit Chinese Med, Zhongshan Hosp Tradit Chinese Med, Dept Cardiol, Zhongshan, Guangdong, Peoples R China
8.Univ Chinese Acad Sci, Beijing, Peoples R China
9.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai, Peoples R China
10.Chinese Acad Sci, SIMM, Zhongshan Inst Drug Discovery, Zhongshan, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Chanda, Francis,Lin, Kai-xuan,Chaurembo, Abdallah Iddy,et al. PM2.5-mediated cardiovascular disease in aging: Cardiometabolic risks, molecular mechanisms and potential interventions[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2024,954:22.
APA Chanda, Francis.,Lin, Kai-xuan.,Chaurembo, Abdallah Iddy.,Huang, Jian-yuan.,Zhang, Hui-juan.,...&Lin, Han-bin.(2024).PM2.5-mediated cardiovascular disease in aging: Cardiometabolic risks, molecular mechanisms and potential interventions.SCIENCE OF THE TOTAL ENVIRONMENT,954,22.
MLA Chanda, Francis,et al."PM2.5-mediated cardiovascular disease in aging: Cardiometabolic risks, molecular mechanisms and potential interventions".SCIENCE OF THE TOTAL ENVIRONMENT 954(2024):22.

入库方式： OAI收割

来源：上海药物研究所

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