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The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring

文献类型：期刊论文

作者Shen, Chunxiang4; Zhu, Xinyi4; Chang, Hao4; Li, Chen4; Hou, Min3,4; Chen, Lin3; Chen, Lu3; Zhou, Zikai1; Ji, Minjun2,3,4; Xu, Zhipeng2,3,4
刊名CELL REPORTS
出版日期2024-10-22
卷号43期号:10页码:23
ISSN号2211-1247
DOI10.1016/j.celrep.2024.114787
通讯作者Zhou, Zikai(zhouzikai@simm.ac.cn) ; Ji, Minjun(jiminjun@njmu.edu.cn) ; Xu, Zhipeng(zhipengxu@njmu.edu.cn)
英文摘要Maternal immune activation (MIA) is critical for imparting neuropathology and altered behaviors in offspring; however, maternal-fetal immune cell populations have not been thoroughly investigated in MIA-induced autism spectrum disorders (ASDs). Here, we report the single-cell transcriptional landscape of placental cells in both PBS- and poly(I:C)-induced MIA dams. We observed a decrease in regulatory T (Treg) cells but an increase in the M1 macrophage population at the maternal-fetal interface in MIA dams. Based on the Treg-targeting approach, we investigate an immunoregulatory protein, the helminth-derived heat shock protein 90a (Sjp90a), that induces maternal Treg cells and subsequently rescues the autism-like behaviors in adult offspring. Furthermore, in vivo depletion of maternal macrophages attenuates placental inflammatory reaction and reverses behavioral abnormalities in adult offspring. Notably, Sjp90a induces CD4(+) T cell differentiation via scavenger receptor A (SR-A) on the macrophage in vitro. . Our findings suggest a maternal Treg-targeted approach to alleviate MIA-induced autism-like behavior in adult offspring.
WOS关键词REGULATORY T-CELLS ; BRAIN-DEVELOPMENT ; PREGNANCY ; CYTOKINES ; BLOOD ; MICROENVIRONMENT ; ACCUMULATION ; ACTIVATION ; TOLERANCE ; RESPONSES
资助项目Natural Science Foundation of Jiangsu Province[BK20211586] ; National Natural Science Foundation of China[82472311] ; State Key Laboratory of Reproductive Medicine and Offspring Health[SKLRM-2021C3] ; State Key Laboratory of Reproductive Medicine and Offspring Health[SKLRM-24KJA310004] ; National Sharing Service Platform for Parasite Resources[TDRC-2019-194-30] ; Medical Scientific Research Project of Jiangsu Provincial Health Commission[Z2021004] ; Natural Science Foundation of the Jiangsu Higher Education Institutions of China[24KTA310004] ; Jiangsu Province Graduate Research Innovation Program[KYCX24_2024] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022013] ; Zhongshan Municipal Bureau of Science and Technology[SQ2302-12]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:001324719700001
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/313645]  
专题中国科学院上海药物研究所
通讯作者Zhou, Zikai; Ji, Minjun; Xu, Zhipeng
作者单位1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China
2.Nanjing Med Univ, NHC Key Lab Antibody Tech, Nanjing 211166, Jiangsu, Peoples R China
3.Jiangsu Prov Key Lab Modern Pathogen Biol, Nanjing 211166, Jiangsu, Peoples R China
4.Nanjing Med Univ, Dept Pathogen Biol & Immunol, State Key Lab Reprod Med & Offspring Hlth, Nanjing 211166, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Shen, Chunxiang,Zhu, Xinyi,Chang, Hao,et al. The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring[J]. CELL REPORTS,2024,43(10):23.
APA Shen, Chunxiang.,Zhu, Xinyi.,Chang, Hao.,Li, Chen.,Hou, Min.,...&Xu, Zhipeng.(2024).The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring.CELL REPORTS,43(10),23.
MLA Shen, Chunxiang,et al."The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring".CELL REPORTS 43.10(2024):23.

入库方式： OAI收割

来源：上海药物研究所

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