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FMP-6-S4 impeded Aβ42 induced SH-SY5Y cell injury by targeting cyclophilin D

文献类型：期刊论文

作者Gao, Pengcheng5,6; Li, Saijuan2,5,6; Wang, Yuyong4; Wu, Fangge5,6; Jin, Can3; Zhao, Danfeng1; Zhang, Haiyan1; Liao, Wenfeng5,6; Ding, Kan3,4,5,6
刊名JOURNAL OF FUNCTIONAL FOODS
出版日期2024-08-01
卷号119页码:9
关键词Alzheimer's disease Fructus Mori Amyloid beta Cyclophilin D Mitochondrial permeability transition pore Glycopeptide
ISSN号1756-4646
DOI10.1016/j.jff.2024.106311
通讯作者Liao, Wenfeng(liaowenfeng@simm.ac.cn) ; Ding, Kan(dingkan@simm.ac.cn)
英文摘要Amyloid beta (A beta) is pivotal in the progression of Alzheimer's disease (AD) by inducing neuron damage. Recent evidences implied that the formation of mitochondrial permeability transition pore (mPTP) was involved in A beta mediated mitochondrial dysfunction. Cyclophilin D (CypD), which is the essential component of mPTP, could interact with A beta and promote mPTP formation, resulting in severe mitochondrial dysfunction and eventually cell death. In this study, we demonstrated that a glycopeptide, FMP-6-S4, purified from the fruit of Fructus Mori bond to CypD and suppressed its expression. Furthermore, FMP-6-S4 markedly inhibited the opening of mPTP, the generation of reactive oxygen species and calcium releasing. Mechanistically study showed that FMP-6-S4 could bind to CypD to disrupt the interaction between CypD and A beta(42). Finally, FMP-6-S4 could bind to A beta(42) directly then attenuate cell damage induced by A beta(42) via p53-puma signaling pathway. Together, our results suggest FMP6-S4 might be a potential candidate for anti-AD drug development.
WOS关键词POLYSACCHARIDE
资助项目Shanghai Municipal Science and Technology Major Project ; National Natural Science Foundation of China[32271332] ; National Natural Science Foundation of China[82374059] ; Lingang Laboratory[LG202101-01-02] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022012]
WOS研究方向Food Science & Technology ; Nutrition & Dietetics
语种英语
WOS记录号WOS:001325499900001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/313648]  
专题新药研究国家重点实验室
通讯作者Liao, Wenfeng; Ding, Kan
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Kweichow Maotai Hosp, Dept Pharm, Zhongshu Cent St, Renhuai 564500, Peoples R China
3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Ave, Nanjing 210023, Peoples R China
5.Univ Chinese Acad Sci, 19 Auquan Rd, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Drug Res Ctr, Key Lab Receptor Res,State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Pengcheng,Li, Saijuan,Wang, Yuyong,et al. FMP-6-S4 impeded Aβ42 induced SH-SY5Y cell injury by targeting cyclophilin D[J]. JOURNAL OF FUNCTIONAL FOODS,2024,119:9.
APA Gao, Pengcheng.,Li, Saijuan.,Wang, Yuyong.,Wu, Fangge.,Jin, Can.,...&Ding, Kan.(2024).FMP-6-S4 impeded Aβ42 induced SH-SY5Y cell injury by targeting cyclophilin D.JOURNAL OF FUNCTIONAL FOODS,119,9.
MLA Gao, Pengcheng,et al."FMP-6-S4 impeded Aβ42 induced SH-SY5Y cell injury by targeting cyclophilin D".JOURNAL OF FUNCTIONAL FOODS 119(2024):9.

入库方式： OAI收割

来源：上海药物研究所

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