An arabinan from Citrus grandis fruits alleviates ischemia/ reperfusion-induced myocardial cell apoptosis via the Nrf2/Keap1 and IRE1/GRP78 signaling pathways
文献类型：期刊论文
| 作者 | Zhang, Shaojie6; Xing, Na5; Jiao, Yukun4; Li, Junhao6; Wang, Tanggan6; Zhang, Qian3; Hu, Xianjing6; Li, Chong1,2; Kuang, Weihong6 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2025 |
| 卷号 | 347页码:19 |
| 关键词 | Citrus grandis Tomentosa Polysaccharide Myocardial ischemia-reperfusion Oxidative stress damage Nrf2/Keap-1 Endoplasmic reticulum stress |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2024.122728 |
| 通讯作者 | Zhang, Shaojie(ZhangSJ_Polymers@163.com) ; Li, Chong(li_chong688@163.com) ; Kuang, Weihong(kuangwh@gdmu.edu.cn) |
| 英文摘要 | Citrus grandis fruit is a famous traditional Chinese medicine with various bioactivities, including cardioprotective effects. Polysaccharides are one of the key active ingredients responsible for its cardioprotective effects. This study aimed to investigate the structure and cardioprotective effect of a homogeneous polysaccharide from C. grandis fruit (CGP80-1) and explore its mechanism against myocardial ischemia-reperfusion (MI/R) injury. Structure analysis showed that CGP80-1 (11,917 Da) is an arabinan with compact coil chain conformation, containing -> 5)-alpha-L-Araf-(1 ->, f-(1 ->, -> 3,5)-alpha-L-Araf-(1 ->, f-(1 ->, and -> 2,3,5)-alpha-L-Araf-(1 -> as the backbone, as well as -> 5)alpha-L-Araf-(1 -> and t-alpha-L-Araf as side-chains substituted at the C2 and C3 positions. Pharmacological experiments showed that pre-treatment with CGP80-1 could effectively alleviate MI/R injury by improving endogenous antioxidant enzymes and cardiac enzymes, reducing reactive oxygen species levels, and regulating apoptosisrelated proteins such as caspase-3, Bax, and Bcl-2. The protective effects were correlated with the Nrf2/Keap1 and IRE1/GRP78 signaling pathways. Further analysis of structure-activity relationships revealed that the myocardial protection effects of CGP80-1 might be attributed to its appropriate molecular weight, high arabinose content, and unique compact coil chain conformation. Overall, our results provide insight into the chemical structure of CGP80-1 and its mechanism of action, suggesting that CGP80-1 could be a candidate drug for myocardial protection. |
| WOS关键词 | ANTIOXIDANT ACTIVITIES ; CHAIN CONFORMATION ; OXIDATIVE STRESS ; POLYSACCHARIDES ; INJURY ; NRF2 ; MECHANISMS ; NMR ; ROS ; CARDIOPROTECTION |
| 资助项目 | Central Public Welfare Research Institutes[4SG24203G] ; Scientific research foundation for the intro-duction of talent[ZZ18-ND-12] ; Medical Scientific Research Foundation of Guangdong Province[QD-2024004B] ; Discipline construction project of Guangdong Medical University[B2023411] ; Guangdong Basic and Applied Basic Research Foundation-Yifang Pharmaceutical Joint Fund[4SG23282G] ; [2023A1515220233] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001322690600001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313678]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Shaojie; Li, Chong; Kuang, Weihong |
| 作者单位 | 1.Shandong Agr Univ, Coll Life Sci, Tai An 271018, Shandong, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Joint Sch Life Sci, CAS Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China 3.Guangdong Pharmaceut Univ, Guangdong Prov Engn Ctr Top Precise Drug Delivery, Sch Pharm, Guangdong Prov Key Lab Adv Drug Delivery, Guangzhou 510006, Peoples R China 4.China Acad Chinese Med Sci, Inst Tradit Chinese Med Hlth Ind, Jiangxi Hlth Ind Inst Tradit Chinese Med, Jiangxi Prov Key Lab Tradit Chinese Med Pharmacol, Nanchang 330115, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China 6.Guangdong Med Univ, Affiliated Dongguan Songshan Lake Cent Hosp, Sch Pharm, Guangdong Prov Key Lab Res & Dev Nat Drugs, Dongguan 523808, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shaojie,Xing, Na,Jiao, Yukun,et al. An arabinan from Citrus grandis fruits alleviates ischemia/ reperfusion-induced myocardial cell apoptosis via the Nrf2/Keap1 and IRE1/GRP78 signaling pathways[J]. CARBOHYDRATE POLYMERS,2025,347:19. |
| APA | Zhang, Shaojie.,Xing, Na.,Jiao, Yukun.,Li, Junhao.,Wang, Tanggan.,...&Kuang, Weihong.(2025).An arabinan from Citrus grandis fruits alleviates ischemia/ reperfusion-induced myocardial cell apoptosis via the Nrf2/Keap1 and IRE1/GRP78 signaling pathways.CARBOHYDRATE POLYMERS,347,19. |
| MLA | Zhang, Shaojie,et al."An arabinan from Citrus grandis fruits alleviates ischemia/ reperfusion-induced myocardial cell apoptosis via the Nrf2/Keap1 and IRE1/GRP78 signaling pathways".CARBOHYDRATE POLYMERS 347(2025):19. |
入库方式： OAI收割
来源：上海药物研究所
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