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The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)

文献类型：期刊论文

作者Wang, Hongdan1,4; Wang, Yunqing1,4; Wang, Qiaoning1,4; Lv, Min1,4; Zhao, Xizhen1,4; Ji, Yunxia3; Han, Xiaoyue1; Wang, Xiaoyan3; Chen, Lingxin1,2,4
刊名JOURNAL OF HAZARDOUS MATERIALS
出版日期2022-10-15
卷号440页码:10
关键词Microplastics Embryonic developmental toxicity Oxidative stress toxicity Cardiotoxicity effects Antagonize toxic effects
ISSN号0304-3894
DOI10.1016/j.jhazmat.2022.129711
通讯作者Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要Microplastics (MPs) have the characteristics of large specific surface area, high hydrophobicity and surface charge, so they are easy to combine with other pollutants and cause toxic effects on aquatic organisms. Here, we prepared a polyvinyl chloride-microplastics (PVC-MPs) fragmentation model to simulate the real microplastic state, and characterized its composition, morphology, particle size and zeta potential. On this basis, we used single and compound exposure of PVC and di(2-ethylhexyl) phthalate (DEHP) to explore their effects on hatchability and mortality of zebrafish (Danio rerio) embryos and toxicity to oxidative stress and cardiac development in zebrafish larvae. Herein, PVC-MPs slowed down the hatching rate of zebrafish embryos and induced the death of zebrafish, while DEHP could slow down the induced of death, it had no effect on hatching rate. The PVC-MPs/DEHP single pollution could induce the reactive oxygen species (ROS) and activated the antioxidant defense signaling pathway, while the compound group showed the level of feedback autoregulation of NF-E2-related factor 2 (Nrf2) signaling pathway. The single pollution also could inhibit the expression of genes related to cardiac development, while the combined pollution showed an antagonistic effect. This study provided a theoretical basis for the ecotoxicology and biomonitoring of MPs in the natural state.
WOS关键词ACCUMULATION ; EXPOSURE ; COASTAL ; WATERS ; GILLS ; DEHP ; FISH
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:001043988000006
资助机构Natural Science Foundation of Shandong Province of China ; National Natural Science Foundation of China ; Science and Technology Innovation Development Plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding
源URL[http://ir.yic.ac.cn/handle/133337/36872]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Chen, Lingxin
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Processes & Ecol Rem, Yantai 264003, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Hongdan,Wang, Yunqing,Wang, Qiaoning,et al. The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,440:10.
APA Wang, Hongdan.,Wang, Yunqing.,Wang, Qiaoning.,Lv, Min.,Zhao, Xizhen.,...&Chen, Lingxin.(2022).The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio).JOURNAL OF HAZARDOUS MATERIALS,440,10.
MLA Wang, Hongdan,et al."The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)".JOURNAL OF HAZARDOUS MATERIALS 440(2022):10.

入库方式： OAI收割

来源：烟台海岸带研究所

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