Norgestrel causes digestive gland injury in the clam Mactra veneriformis: An integrated histological, transcriptomics, and metabolomics study
文献类型：期刊论文
| 作者 | Zhao, Xiaoran1; Wang, Qing2 ; Li, Xiangfei1; Xu, Hua3; Ren, Chuanbo4; Yang, Yanyan4; Xu, Shuhao1; Wei, Guoxing1; Duan, Yujun1; Tan, Zhitao1
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2023-05-01 |
| 卷号 | 871页码:13 |
| 关键词 | Progestin Histology Transcriptome Metabolome Bivalve |
| ISSN号 | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2023.162110 |
| 通讯作者 | Fang, Yan(fly12689@163.com) |
| 英文摘要 | The potential adverse effects of progestins on aquatic organisms, especially non-target species, are of increasing concern worldwide. However, the effect and mechanism of progestin toxicity on aquatic invertebrates remain largely unexplored. In the present study, clams Mactra veneriformis were exposed to norgestrel (NGT, 0,10, and 1000 ng/L), the dominant progestin detected in the aquatic environment, for 21 days. NGT accumulation, histology, transcriptome, and metabolome were assessed in the digestive gland. The bioconcentration factor (BCF) was 386 and 268 in the 10 ng/L NGT group and 1000 ng/L NGT group, respectively, indicating efficient accumulation of NGT in the clams. Histological analysis showed that NGT led to the swelling of epithelial cells and blurring of the basement membrane in the digestive gland. Differentially-expressed genes and KEGG pathway enrichment analysis using a transcriptomic approach suggested that NGT primarily disturbed the detoxification system, antioxidant defense, carbohydrate and amino acid metabolism, and steroid hormone metabolism, which was consistent with the metabolites analyzed using a metabolomic approach. Furthermore, we speculated that the oxidative stress caused by NGT resulted in histological damage to the digestive gland. This study showed that NGT caused adverse effects in the clams and sheds light on the mechanisms of progestin interference in aquatic invertebrates. |
| WOS关键词 | MOSQUITOFISH GAMBUSIA-AFFINIS ; AFFECTS SEX-DIFFERENTIATION ; ACUTE REGULATORY PROTEIN ; MEDROXYPROGESTERONE ACETATE ; MYTILUS-GALLOPROVINCIALIS ; BIOTRANSFORMATION ENZYMES ; STEROID-LEVELS ; LIFE-HISTORY ; EXPOSURE ; EXPRESSION |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:000990537800001 |
| 资助机构 | National Natural Science Founda- tion of China ; National Key Research and Devel- opment Program of China ; Ludong University Research Funding |
| 源URL | [http://ir.yic.ac.cn/handle/133337/36932]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 中国科学院牟平海岸带环境综合试验站 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Fang, Yan |
| 作者单位 | 1.Ludong Univ, Sch Agr, Yantai 264025, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Peoples R China 3.Yantai Ecol Environm Monitoring Ctr, Yantai 264010, Shandong, Peoples R China 4.Shandong Marine Resource & Environm Res Inst, Shandong Prov Key Lab Restorat Marine Ecol, Yantai 264006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Xiaoran,Wang, Qing,Li, Xiangfei,et al. Norgestrel causes digestive gland injury in the clam Mactra veneriformis: An integrated histological, transcriptomics, and metabolomics study[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2023,871:13. |
| APA | Zhao, Xiaoran.,Wang, Qing.,Li, Xiangfei.,Xu, Hua.,Ren, Chuanbo.,...&Fang, Yan.(2023).Norgestrel causes digestive gland injury in the clam Mactra veneriformis: An integrated histological, transcriptomics, and metabolomics study.SCIENCE OF THE TOTAL ENVIRONMENT,871,13. |
| MLA | Zhao, Xiaoran,et al."Norgestrel causes digestive gland injury in the clam Mactra veneriformis: An integrated histological, transcriptomics, and metabolomics study".SCIENCE OF THE TOTAL ENVIRONMENT 871(2023):13. |
入库方式： OAI收割
来源：烟台海岸带研究所
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