Potential roles of MEK1 on aging in Argopecten scallops
文献类型：期刊论文
| 作者 | Yuan, Ke1,2; Lu, Xia1 ; Ning, Junhao1; Chen, Min1; Wang, Quanchao1,3; Liu, Guilong3; Xu, Xin3; Xu, He4; Wang, Chunde1,3
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| 刊名 | FRONTIERS IN MARINE SCIENCE
 |
| 出版日期 | 2022-11-18 |
| 卷号 | 9页码:16 |
| 关键词 | bivalve Argopecten scallops MEK1 aging nutrition restriction |
| DOI | 10.3389/fmars.2022.1057814 |
| 通讯作者 | Lu, Xia(xialu@yic.ac.cn) ; Wang, Chunde(chendewang2007@163.com) |
| 英文摘要 | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) has been found to regulate aging through the Ras/Raf/MEK/ERK cascade in terrestrial animals. However, few reports have focused on MEK1 promoting aging in marine bivalves. In this study, we aimed to examine the potential roles of MEK1 in the regulation of aging in two Argopecten scallops, the bay scallop A. irradians and the Peruvian scallop A. purpuratus, which are closely related but with distinct lifespan. The complete ORFs of AiiMEK1 and ApuMEK1 were both 1209 bp, encoding 403 identical amino acids but with 41 synonymous SNPs, which may have contributed to the different activities of MEK1 in two scallops. Nutrient restriction, one of the most effective non-genetic means of promoting life span, significantly inhibit the expression of AiiMEK1 and ApuMEK1. The response in hepatopancreas of A. irradians to nutrient restriction was more persistently than that in A. purpuratus. RNAi of AiiMEK1 significantly increased the expression of its downstream genes known to favor longevity, such as FoxO and SOD, while decreased the expression of ERK1/2 and the key genes in the mTOR signaling pathway, as well as the beta-GAL activity (a marker for senescence). These results indicated that AiiMEK1 may play a negative role in longevity through Ras/Raf/MEK/ERK pathway. Our results may provide new perspective for understanding of the conservative functions of MEK1 in regulation of aging in animals and benefit the genetic selection of scallops. |
| WOS关键词 | LIFE-SPAN ; TRANSCRIPTION FACTOR ; PROTEIN-KINASES ; ERK ; AGE ; LONGEVITY ; AUTOPHAGY ; GROWTH ; EXPRESSION ; STRESS |
| WOS研究方向 | Environmental Sciences & Ecology ; Marine & Freshwater Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000912217400001 |
| 资助机构 | National Natural Science Foundation of China ; Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province ; Scientific and Technological Project of Yantai, Shandong Province ; Earmarked Fund for Shandong Modern Agro-Industry Technology Research System ; Science and technology smes innovation capacity improvement project in Shandong Province |
| 源URL | [http://ir.yic.ac.cn/handle/133337/37072]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Lu, Xia; Wang, Chunde |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai, Shandong, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Yantai Spring Sea AquaSeed Ltd, Yantai, Peoples R China 4.Jiangsu Haitai MariTech Co Ltd, Jiangsu Baoyuan Biotechnol Co Ltd, Lianyungang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Ke,Lu, Xia,Ning, Junhao,et al. Potential roles of MEK1 on aging in Argopecten scallops[J]. FRONTIERS IN MARINE SCIENCE,2022,9:16. |
| APA | Yuan, Ke.,Lu, Xia.,Ning, Junhao.,Chen, Min.,Wang, Quanchao.,...&Wang, Chunde.(2022).Potential roles of MEK1 on aging in Argopecten scallops.FRONTIERS IN MARINE SCIENCE,9,16. |
| MLA | Yuan, Ke,et al."Potential roles of MEK1 on aging in Argopecten scallops".FRONTIERS IN MARINE SCIENCE 9(2022):16. |
入库方式： OAI收割
来源：烟台海岸带研究所
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