中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 烟台海岸带研究所
  3. 中国科学院烟台海岸带研究所
  4. 中科院海岸带环境过程与生态修复重点实验室
Toxicological effects of tris(1,3-dichloro-2-propyl) phosphate in oyster Crassostrea gigas using proteomic and phosphoproteomic analyses

文献类型：期刊论文

作者Yin, Chengcheng1,3; Sun, Zuodeng5; Ji, Chenglong2,3,4; Li, Fei2,3; Wu, Huifeng2,3,4
刊名JOURNAL OF HAZARDOUS MATERIALS
出版日期2022-07-15
卷号434页码:12
关键词Tris(1 3-dichloro-2-propyl) phosphate Crassostrea gigas Proteomics Phosphoproteomics
ISSN号0304-3894
DOI10.1016/j.jhazmat.2022.128824
通讯作者Ji, Chenglong(clji@yic.ac.cn) ; Wu, Huifeng(hfwu@yic.ac.cn)
英文摘要As a typical organophosphorus pollutant, tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been widely detected in aquatic environment. Previous studies showed that protein phosphorylation might be a vital way of TDCIPP to exert multiple toxic effects. However, there is a lack of high-throughput investigations on how TDCIPP affected protein phosphorylation. In this study, the toxicological effects of TDCIPP were explored by proteomic and phosphoproteomic analyses together with traditional means in oysters Crassostrea gigas treated with 0.5, 5 and 50 mu g/L TDCIPP for 28 days. Integration of omic analyses revealed that TDCIPP dysregulated transcription, energy metabolism, and apoptosis and cell proliferation by either directly phosphorylating pivotal proteins or phosphorylating their upstream signaling pathways. The U-shaped response of acetylcholinesterase activities suggested the neurotoxicity of TDCIPP in a hormesis manner. What's more, the increase in caspase-9 activity as well as the expression or phosphorylation alterations in eukaryotic translation initiation factor 4E, cell division control protein 42 and transforming growth factor-beta 1-induced protein indicated the disruption of homeostasis between apoptosis and cell proliferation, which was consistent with the observation of shedding of digestive cells. Overall, combination of proteomic and phosphoproteomic analyses showed the capability of identifying molecular events, which provided new insights into the toxicological mechanisms of TDCIPP.
WOS关键词ORGANOPHOSPHORUS FLAME RETARDANTS ; QUANTITATIVE ALTERATIONS ; PROSTATE-CANCER ; CELL ; PHOSPHORYLATION ; METABOLISM ; EXPOSURE ; GROWTH ; BIOCONCENTRATION ; PROLIFERATION
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000793533900002
资助机构National Natural Science Foundation of China ; Yantai Science and Technology Development Plan
源URL[http://ir.yic.ac.cn/handle/133337/37467]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_近岸生态与环境实验室
通讯作者Ji, Chenglong; Wu, Huifeng
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China
4.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China
5.Shandong Fisheries Dev & Resource Conservat Ctr, Jinan 250013, Peoples R China
推荐引用方式
GB/T 7714		 Yin, Chengcheng,Sun, Zuodeng,Ji, Chenglong,et al. Toxicological effects of tris(1,3-dichloro-2-propyl) phosphate in oyster Crassostrea gigas using proteomic and phosphoproteomic analyses[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,434:12.
APA Yin, Chengcheng,Sun, Zuodeng,Ji, Chenglong,Li, Fei,&Wu, Huifeng.(2022).Toxicological effects of tris(1,3-dichloro-2-propyl) phosphate in oyster Crassostrea gigas using proteomic and phosphoproteomic analyses.JOURNAL OF HAZARDOUS MATERIALS,434,12.
MLA Yin, Chengcheng,et al."Toxicological effects of tris(1,3-dichloro-2-propyl) phosphate in oyster Crassostrea gigas using proteomic and phosphoproteomic analyses".JOURNAL OF HAZARDOUS MATERIALS 434(2022):12.

入库方式： OAI收割

来源：烟台海岸带研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。