Potential Roles of PTEN on Longevity in Two Closely Related Argopecten Scallops With Distinct Lifespans
文献类型：期刊论文
| 作者 | Xu, Hanzhi2; Lu, Xia2 ; Wang, Chunde2,3; Ning, Junhao2; Chen, Min2; Wang, Yuan1,2; Yuan, Ke1,2
|
| 刊名 | FRONTIERS IN PHYSIOLOGY
 |
| 出版日期 | 2022-07-12 |
| 卷号 | 13页码:14 |
| 关键词 | bivalve Argopecten scallops PTEN nutrition restriction genomic stability PI3K Akt FoxO |
| DOI | 10.3389/fphys.2022.872562 |
| 通讯作者 | Lu, Xia(xialu@yic.ac.cn) |
| 英文摘要 | Phosphatase and tensin homolog deleted on chromosome ten (PTEN) has been found to regulate longevity through the PI3K/Akt/FoxO pathway and maintenance of genome integrity in worms, flies, and mammals. However, limited information is available on the roles of PTEN in longevity of aquatic animals. Here we extended this paradigm using two closely related Argopecten scallops, Argopecten purpuratus, and Argopecten irradians, with significantly distinct life spans, which are commercially important bivalve species for fishery and aquaculture in China, United States, Peru, and Chile. The ORFs of the ApPTEN and AiPTEN were 1,476 and 1,473 bp, which encoded 491 and 490 amino acids, respectively. There were 48 synonymous and 16 non-synonymous SNPs and one InDel of three nucleotides between ApPTEN and AiPTEN, resulting in variations in 15 amino acids and lack of S453 in AiPTEN. Differences in conformation and posttranslational modification were predicted between ApPTEN and AiPTEN, which may indicate different activities of ApPTEN and AiPTEN. When the animals were subjected to nutrition restriction, the expression of both ApPTEN and AiPTEN was upregulated, with AiPTEN responded faster and more robust than ApPTEN. Ionizing radiation induced significantly elevated expression of ApPTNE but not AiPTEN in the adductor muscle, and the mortality rate of A. purpuratus was significantly lower than that of A. irradians, indicating that ApPTNE may play a protective role by maintaining the genome integrity. RNAi of ApPTNE significantly downregulated the expression of its downstream regulated genes known to favor longevity, such as FoxO, Mn-SOD, and CAT. These results indicated that PTEN may contribute to the longevity of A. purpuratus through regulation of nutrient availability and genomic stability, probably via PI3K/Akt/FoxO pathway. Our study may provide new evidence for understanding of the conservative functions of PTEN in regulation of lifespan in animals and human, and it may also benefit the selection of scallops strains with long lifespan and thus larger size. |
| WOS关键词 | TUMOR-SUPPRESSOR PTEN ; MOLECULAR CHARACTERIZATION ; IRRADIANS LAMARCK ; BAY SCALLOP ; PROTEIN ; PHOSPHORYLATION ; FOXO ; STABILITY ; PATHWAY ; BRAIN |
| WOS研究方向 | Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000831937600001 |
| 资助机构 | National Natural Science Foundation of China ; Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province ; Scientific and Technological Project of Yantai, Shandong Province ; Earmarked Fund for Shandong Modern Agro-Industry Technology Research System |
| 源URL | [http://ir.yic.ac.cn/handle/133337/37371]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Lu, Xia |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai, Peoples R China 3.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Hanzhi,Lu, Xia,Wang, Chunde,et al. Potential Roles of PTEN on Longevity in Two Closely Related Argopecten Scallops With Distinct Lifespans[J]. FRONTIERS IN PHYSIOLOGY,2022,13:14. |
| APA | Xu, Hanzhi.,Lu, Xia.,Wang, Chunde.,Ning, Junhao.,Chen, Min.,...&Yuan, Ke.(2022).Potential Roles of PTEN on Longevity in Two Closely Related Argopecten Scallops With Distinct Lifespans.FRONTIERS IN PHYSIOLOGY,13,14. |
| MLA | Xu, Hanzhi,et al."Potential Roles of PTEN on Longevity in Two Closely Related Argopecten Scallops With Distinct Lifespans".FRONTIERS IN PHYSIOLOGY 13(2022):14. |
入库方式： OAI收割
来源：烟台海岸带研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。