Preparation of Doxorubicin-Loaded Carboxymethyl-beta-Cyclodextrin/Chitosan Nanoparticles with Antioxidant, Antitumor Activities and pH-Sensitive Release
文献类型：期刊论文
| 作者 | Mi, Yingqi1,2; Zhang, Jingjing2; Tan, Wenqiang2 ; Miao, Qin1,2; Li, Qing2; Guo, Zhanyong1,2
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2022-05-01 |
| 卷号 | 20期号:5页码:18 |
| 关键词 | chitosan nanoparticles cyclodextrin antioxidant activity antitumor activity drug release |
| DOI | 10.3390/md20050278 |
| 通讯作者 | Guo, Zhanyong(zhanyongguo@hotmail.com) |
| 英文摘要 | In this study, chitosan nanoparticles (HF-CD NPs) were synthesized by an ionic gelation method using negatively charged carboxymethyl-beta-cyclodextrin and positively charged 2-hydroxypropyltrimethyl ammonium chloride chitosan bearing folic acid. The surface morphology of HF-CD NPs was spherical or oval, and they possessed relatively small particle size (192 +/- 8 nm) and positive zeta potential (+20 +/- 2 mV). Meanwhile, doxorubicin (Dox) was selected as model drug to investigate the prepared nanoparticles' potential to serve as a drug delivery carrier. The drug loading efficiency of drug-loaded nanoparticles (HF-Dox-CD NPs) was 31.25%. In vitro release profiles showed that Dox release of nanoparticles represented a pH-sensitive sustained and controlled release characteristic. At the same time, the antioxidant activity of nanoparticles was measured, and chitosan nanoparticles possessed good antioxidant activity and could inhibit the lipid peroxidation inside the cell and avoid material infection. Notably, CCK-8 assay testified that the nanoparticles were safe drug carriers and significantly enhanced the antitumor activity of Dox. The nanoparticles possessed good antioxidant activity, pH-sensitive sustained controlled release, enhanced antitumor activity, and could be expected to serve as a drug carrier in future with broad application prospects. |
| WOS关键词 | CHITOSAN NANOPARTICLES |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000801303600001 |
| 资助机构 | National Key R&D Program of China ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China ; Chinese Academy of Sciences |
| 源URL | [http://ir.yic.ac.cn/handle/133337/37503]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Guo, Zhanyong |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mi, Yingqi,Zhang, Jingjing,Tan, Wenqiang,et al. Preparation of Doxorubicin-Loaded Carboxymethyl-beta-Cyclodextrin/Chitosan Nanoparticles with Antioxidant, Antitumor Activities and pH-Sensitive Release[J]. MARINE DRUGS,2022,20(5):18. |
| APA | Mi, Yingqi,Zhang, Jingjing,Tan, Wenqiang,Miao, Qin,Li, Qing,&Guo, Zhanyong.(2022).Preparation of Doxorubicin-Loaded Carboxymethyl-beta-Cyclodextrin/Chitosan Nanoparticles with Antioxidant, Antitumor Activities and pH-Sensitive Release.MARINE DRUGS,20(5),18. |
| MLA | Mi, Yingqi,et al."Preparation of Doxorubicin-Loaded Carboxymethyl-beta-Cyclodextrin/Chitosan Nanoparticles with Antioxidant, Antitumor Activities and pH-Sensitive Release".MARINE DRUGS 20.5(2022):18. |
入库方式： OAI收割
来源：烟台海岸带研究所
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