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Neural mechanisms underlying placebo and nocebo effects in tonic muscle pain

文献类型：期刊论文

作者Chen, Min8; Wu, Xiao5,6,7; Zhang, Libo5,6; Zhang, Fengrui5,6; Li, Linling4; Zhang, Yingying3; Xiong, Donglin2; Qiu, Yunhai4; Hu, Li5,6; Xiao, Weibo1,2
刊名NEUROIMAGE
出版日期2024-10-15
卷号300页码:13
关键词Placebo analgesia Nocebo hyperalgesia Tonic muscle pain Functional magnetic resonance imaging (fMRI) Putamen Caudate
ISSN号1053-8119
DOI10.1016/j.neuroimage.2024.120877
通讯作者Hu, Li(huli@psych.ac.cn) ; Xiao, Weibo(xiaoweibo820901@163.com)
英文摘要Pain is a highly subjective and multidimensional experience, significantly influenced by various psychological factors. Placebo analgesia and nocebo hyperalgesia exemplify this influence, where inert treatments result in pain relief or exacerbation, respectively. While extensive research has elucidated the psychological and neural mechanisms behind these effects, most studies have focused on transient pain stimuli. To explore these mechanisms in the context of tonic pain, we conducted a study using a 15-minute tonic muscle pain induction procedure, where hypertonic saline was infused into the left masseter of healthy participants. We collected real-time Visual Analogue Scale (VAS) scores and functional magnetic resonance imaging (fMRI) data during the induction of placebo analgesia and nocebo hyperalgesia via conditioned learning. Our findings revealed that placebo analgesia was more pronounced and lasted longer than nocebo hyperalgesia. Real-time pain ratings correlated significantly with neural activity in several brain regions. Notably, the putamen was implicated in both effects, while the caudate and other regions were differentially involved in placebo and nocebo effects. These findings confirm that the tonic muscle pain paradigm can be used to investigate the mechanisms of placebo and nocebo effects and indicate that placebo analgesia and nocebo hyperalgesia may have more distinct than common neural bases.
收录类别SCI
WOS关键词PARTIAL-REINFORCEMENT ; SOMATOSENSORY CORTEX ; CAUDATE-NUCLEUS ; FMRI ; HYPERALGESIA ; EXPERIENCE ; EXTINCTION ; INTENSITY ; PUTAMEN ; BRAIN
资助项目National Key Research and Development Program of China[2023YFC2508702] ; National Natural Science Foundation of China[32071061] ; Beijing Natural Science Foundation[JQ22018] ; Medical Science and Technology Research Fund of Guangdong Province[A2021478] ; Hundred Talents Program of Chinese Academy of Sciences[Y14408] ; Shenzhen Science and Technology Program[JC201005270293A] ; Joint Laboratory for Basic Research of Neuropathic Pain[Y4Z050]
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:001330900900001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Medical Science and Technology Research Fund of Guangdong Province ; Hundred Talents Program of Chinese Academy of Sciences ; Shenzhen Science and Technology Program ; Joint Laboratory for Basic Research of Neuropathic Pain
源URL[http://ir.psych.ac.cn/handle/311026/49111]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Hu, Li; Xiao, Weibo
作者单位1.Loudi Cent Hosp, Dept Anesthesiol, Loudi, Hunan Province, Peoples R China
2.Nanshan Hosp Shenzhen City, Guangdong Med Coll, Dept Pain, Shenzhen, Guangdong Provi, Peoples R China
3.Loudi Cent Hosp, Dept Neurol, Loudi, Hunan Province, Peoples R China
4.Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Neural Engn, Shenzhen, Guangdong Provi, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
8.Shenzhen Samii Med Ctr, Dept Anesthesiol, Shenzhen, Guangdong Provi, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Min,Wu, Xiao,Zhang, Libo,et al. Neural mechanisms underlying placebo and nocebo effects in tonic muscle pain[J]. NEUROIMAGE,2024,300:13.
APA Chen, Min.,Wu, Xiao.,Zhang, Libo.,Zhang, Fengrui.,Li, Linling.,...&Xiao, Weibo.(2024).Neural mechanisms underlying placebo and nocebo effects in tonic muscle pain.NEUROIMAGE,300,13.
MLA Chen, Min,et al."Neural mechanisms underlying placebo and nocebo effects in tonic muscle pain".NEUROIMAGE 300(2024):13.

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来源：心理研究所

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