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Sex differences in plasma lipid profiles, but not in glucose metabolism in patients with first-episode antipsychotics-naive schizophrenia

文献类型：期刊论文

作者Li, Shen3,4; Liu, Nannan3,4; Qi, Dan3,4; Niu, Lichao3,4; Li, Yanzhe3,4; Lu, Chenghao3,4; Dong, Yeqing3,4; Wang, Xinxu3,4; Li, Jie4; Zhang, Xiangyang1,2
刊名BRAIN RESEARCH
出版日期2025
卷号1846页码:7
关键词Schizophrenia First-episode antipsychotics-naive Glycolipid metabolism OGTT Sex differences
ISSN号0006-8993
DOI10.1016/j.brainres.2024.149282
通讯作者Li, Jie(jieli@tjmhc.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Background: First-episode antipsychotics-na & iuml;ve schizophrenia (FEAN-SCZ) is associated with abnormalities in glucose and lipid metabolism. While sex differences in the incidence and severity of SCZ and metabolic abnormalities have been documented, the specific metabolic abnormalities between the sexes remain unclear. The study aimed to investigate sex-specific differences in plasma glycolipid profiles in FEAN-SCZ patients. Methods: A total of 172 FEAN-SCZ patients (male/female: 83/89) and 31 healthy controls (male/female: 14/17) were recruited. Psychopathology assessment was conducted using the Positive and Negative Syndrome Scale (PANSS). Glycolipid profiles, including oral glucose tolerance test (OGTT), fasting glucose, insulin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were examined in all participants. Results: FEAN patients displayed significantly higher fasting and 2-hour glucose levels compared to healthy controls (both p < 0.001). Impaired glucose tolerance (IGT) prevalence in male patients was 24.1 % (n = 20) and 25.9 % (n = 23) in females, contrasting with 0 % (n = 0) in the control group. FEAN patients exhibited elevated blood insulin and TC levels (both p < 0.05) and increased insulin resistance measured by HOMA-IR (p < 0.01). Among male patients, those with IGT had significantly higher TC, TG and LDL levels than non-IGT patients (all p < 0.05), while no significant differences were observed in female patients between IGT and non-IGT groups. Body mass index (BMI), TG and HDL levels were identified as significant predictors of IGT in male FEAN patients. Conclusions: IGT is present in a subset of FEAN-SCZ patients. Male patients with IGT exhibit distinct alterations in plasma lipid profiles compared to non-IGT patients.
收录类别SCI
WOS关键词GENDER-DIFFERENCES ; PSYCHOSIS ; TOLERANCE ; INSULIN ; RISK ; METAANALYSIS ; ASSOCIATION ; PREVALENCE ; MECHANISMS ; MORTALITY
资助项目National Natural Science Foundation of China[82371512] ; Tianjin Key Medical Discipline (Specialty) Con-struction Project[TJYXZDXK-033A] ; Tianjin Health Research Project for Young Scholars[TJWJ2021QN064]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:001343375500001
出版者ELSEVIER
资助机构National Natural Science Foundation of China ; Tianjin Key Medical Discipline (Specialty) Con-struction Project ; Tianjin Health Research Project for Young Scholars
源URL[http://ir.psych.ac.cn/handle/311026/49182]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Li, Jie; Zhang, Xiangyang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Tianjin Med Univ, Tianjin Anding Hosp, Brain Assessment & Intervent Lab, Mental Hlth Ctr, Tianjin 300222, Peoples R China
4.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Mental Hlth Ctr, Tianjin 300222, Peoples R China
推荐引用方式
GB/T 7714		 Li, Shen,Liu, Nannan,Qi, Dan,et al. Sex differences in plasma lipid profiles, but not in glucose metabolism in patients with first-episode antipsychotics-naive schizophrenia[J]. BRAIN RESEARCH,2025,1846:7.
APA Li, Shen.,Liu, Nannan.,Qi, Dan.,Niu, Lichao.,Li, Yanzhe.,...&Zhang, Xiangyang.(2025).Sex differences in plasma lipid profiles, but not in glucose metabolism in patients with first-episode antipsychotics-naive schizophrenia.BRAIN RESEARCH,1846,7.
MLA Li, Shen,et al."Sex differences in plasma lipid profiles, but not in glucose metabolism in patients with first-episode antipsychotics-naive schizophrenia".BRAIN RESEARCH 1846(2025):7.

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来源：心理研究所

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