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Carrier Polymer-Free Dissolvable Microneedles Enable Superhigh Drug Payload for Percutaneous Protein Delivery

文献类型：期刊论文

作者Wang, Zhao5; Liu, Lin3,4; Liu, Ergang3; Chen, Rongli3; Huang, Yongzhuo1,2,3,4; Li, Qianbin5
刊名ACS MATERIALS LETTERS
出版日期2024-10-07
页码8
DOI10.1021/acsmaterialslett.4c01164
通讯作者Liu, Ergang(liuergang@zidd.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn) ; Li, Qianbin(qbli@csu.edu.cn)
英文摘要Microneedle (MN) patches present a painless alternative for transdermal delivery of monoclonal antibodies (mAbs), yet existing dissolvable MNs are hindered by a low drug-loading capacity (DLC). This study introduces a carrier-free approach for fabricating mAb MNs by a solution-casting method, providing a superhigh drug-payload MN platform (DLC around 70%). Additionally, the use of concentrated proteins prevents interpenetration between the backing layer and the tip, assuring the dosage accuracy of the therapeutic antibodies. Physicochemical characteristics, including mechanical strength, dissolvability, and skin permeability, were evaluated and compared with conventional PVP K17 (poly(vinylpyrrolidone), K17) microneedles. Finally, the transdermal performance of protein dMNs was assessed using IL-17A (Iinterleukin-17A) antibody as a model protein drug, with in vivo therapeutic efficacy evaluated in a psoriatic mouse model. The results demonstrate the feasibility and effectiveness of excipient-free dMNs for mAb delivery, significantly improving the drug-loading capacity, while mitigating safety concerns associated with carrier polymers.
WOS关键词TRANSDERMAL DELIVERY ; VACCINES ; PAIN
资助项目National Key Research and Development Program of China[2021YFE0103100] ; National Key Research and Development Program of China[2022YFE0203600] ; NFSC[81925035] ; NFSC[82341232] ; Grand Challenges[083GJHZ2023021GC] ; Future Network of the International Partnership Program[083GJHZ2023012FN] ; President's International Fellowship Initiative of Chinese Academy of Sciences[2024VBB0004] ; Department of Science and Technology of Guangdong Province[2019B090904008] ; Department of Science and Technology of Guangdong Province[2021B0909050003] ; Scientific Innovation Group Project in Zhongshan[LJ2021001] ; Scientific Innovation Group Project in Zhongshan[CXTD2022011]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:001330668100001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/313775]  
专题新药研究国家重点实验室
通讯作者Liu, Ergang; Huang, Yongzhuo; Li, Qianbin
作者单位1.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China
4.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China
5.Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Zhao,Liu, Lin,Liu, Ergang,et al. Carrier Polymer-Free Dissolvable Microneedles Enable Superhigh Drug Payload for Percutaneous Protein Delivery[J]. ACS MATERIALS LETTERS,2024:8.
APA Wang, Zhao,Liu, Lin,Liu, Ergang,Chen, Rongli,Huang, Yongzhuo,&Li, Qianbin.(2024).Carrier Polymer-Free Dissolvable Microneedles Enable Superhigh Drug Payload for Percutaneous Protein Delivery.ACS MATERIALS LETTERS,8.
MLA Wang, Zhao,et al."Carrier Polymer-Free Dissolvable Microneedles Enable Superhigh Drug Payload for Percutaneous Protein Delivery".ACS MATERIALS LETTERS (2024):8.

入库方式： OAI收割

来源：上海药物研究所

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