Synergism of salvianolic acid B and ginsenoside Rg1 magnifies the therapeutic potency against ischemic stroke
文献类型：期刊论文
| 作者 | Shen, Haishang5,6; Zhang, Yuhan5,6; Shao, Yanan4,5; Chen, Siqi5,6; Yin, Ping3; Liu, Xin3; Wang, Linlin5; Zhang, Lingxiao5; Jin, Yi2; Wang, Yiyu5 |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2024-11-06 |
| 卷号 | 35期号:16页码:1041-1051 |
| 关键词 | Bliss independence statistical model ginsenoside Rg1 glycerophospholipid metabolism ischemic stroke salvianolic acid B synergistic effect |
| ISSN号 | 0959-4965 |
| DOI | 10.1097/WNR.0000000000002099 |
| 通讯作者 | Jiang, Baohong(jiangbh@simm.ac.cn) |
| 英文摘要 | Even though considerable progress has been made to reduce insult, ischemic stroke is still a significant cause of mortality and morbidity in the world, and new therapeutic strategies are urgently needed. In the present study, the magnesium salt of salvianolic acid B (SalB) and ginsenoside Rg1 (Rg1) combination as a multicomponent strategy against stroke was evaluated. The synergistic effect of Sa1B and Rg1 was evaluated by Bliss independence analysis on the middle cerebral artery occlusion model. The infarct volume, neuroethology, cerebral structure, and neurocyte number were evaluated by 3,5-triphenyltetrazolium chloride staining, Longa score, Garcia score, hematoxylin-eosin staining, and Nissl staining, respectively. Metabolomics was used to search for potential biomarkers and explore the mechanism of Sa1B/Rg1. First, the superior effects of SalB/Rg1 than SalB or Rg1 at the same dose were evaluated. Compared with SalB (P < 0.001) or Rg1 (P < 0.01), SalB/Rg1 significantly decreased infarct volume through 3,5-triphenyltetrazolium chloride staining and protected the structural integrity of cortex and striatum. The superior effect of SalB/Rg1 on neurological behavior was also detected compared with SalB or Rg1 significantly. Accompanying behavioral improvement, a considerable increase of SalB/Rg1 on neurons detected by Nissl staining was found on the cortex compared with SalB (P < 0.05) or Rg1 (P < 0.01). Second, the synergistic effect between SalB and Rg1 was strictly verified by Bliss independence analysis (P < 0.01) based on infarct volume. Finally, alleviation of cerebral metabolic disorders may be the possible mechanism of SalB/Rg1. Our study provided a multicomponent strategy against ischemic stroke, with not only dose reduction but also improved efficacy relative to single agents. Copyright (c) 2024 The Author(s). Published by Wolters Kluwer Health, Inc. |
| WOS关键词 | MYOCARDIAL-INFARCTION ; COMBINATION ; TRYPTOPHAN |
| 资助项目 | National Key R&D Program of China[2021YFE0111300] ; National Key R&D Program of China[2021YFF0702200] ; National Key R&D Program of China[2021YFF0702204] ; Biological Resources Programme, Chinese Academy of Sciences[KFJ-BRP-008-005] ; Shanghai Science and Technology Development Foundation[21S21901900] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001330982500003 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313787]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Jiang, Baohong |
| 作者单位 | 1.Takarazuka Univ Med & Hlth Care, Takarazuka, Hyogo, Japan 2.Shenzhen Inst Drug Control, Shenzhen Testing Ctr Med Devices, Shenzhen, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 6.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Haishang,Zhang, Yuhan,Shao, Yanan,et al. Synergism of salvianolic acid B and ginsenoside Rg1 magnifies the therapeutic potency against ischemic stroke[J]. NEUROREPORT,2024,35(16):1041-1051. |
| APA | Shen, Haishang.,Zhang, Yuhan.,Shao, Yanan.,Chen, Siqi.,Yin, Ping.,...&Jiang, Baohong.(2024).Synergism of salvianolic acid B and ginsenoside Rg1 magnifies the therapeutic potency against ischemic stroke.NEUROREPORT,35(16),1041-1051. |
| MLA | Shen, Haishang,et al."Synergism of salvianolic acid B and ginsenoside Rg1 magnifies the therapeutic potency against ischemic stroke".NEUROREPORT 35.16(2024):1041-1051. |
入库方式： OAI收割
来源：上海药物研究所
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