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Biomimetic nanoreactor of catalase and nitric oxide enhance peroxynitrite generation for radiosensitization

文献类型：期刊论文

作者Wu, Yao3,4,6,7; Li, Yongping5; Xie, Honglei2; Zhang, Yichen3,4; Bao, Xinyue3,4; Sha, Xianyi3,4; Wen, Jingyuan1; Li, Yaping6,7; Zhang, Zhiwen2,3,4
刊名NANO TODAY
出版日期2024-12-01
卷号59页码:12
关键词Radiotherapy Peroxynitrite Nanoreactor Hypoxia Radiosensitization
ISSN号1748-0132
DOI10.1016/j.nantod.2024.102519
通讯作者Li, Yaping(ypli@simm.ac.cn) ; Zhang, Zhiwen(zhangzhiwen@fudan.edu.cn)
英文摘要The redundant DNA-repairing capacity and robust hypoxia in tumors pose significant challenges of cancer radiotherapy. Herein, an amphiphilic nitric oxide (NO)-supplying conjugate (PEG-SMA-NO) was synthesized and integrated with oxygen-producing catalase (CAT) to fabricate a biomimetic nanoreactor (termed as CAT@PNN), aiming to enhance peroxynitrite generation upon X-ray radiation for radiosensitization. CAT@PNN effectively reduced the hypoxic levels and produced abundant NO molecules in tumors. Upon X-ray radiation, excessive peroxynitrite radicals were generated with profound spatiotemporal distribution profiles, which effectively downregulated the expression of DNA-repairing RAD51, reduced the proportion of cancer-stem like cells, and enhanced the levels of DNA damages, cell apoptosis and lipid peroxidation to aid radiosensitization. Specifically, the combination of single treatment of CAT@PNN with X-ray radiation resulted in a 95.41 % inhibition of tumor growth and significantly extended survival in 4T1 tumor model. Therefore, the biomimetic nanoreactor of CAT@PNN offers a promising peroxynitrite-generating nanoplatform to enhance radiosensitization in cancer radiotherapy.
WOS关键词BIOCHEMISTRY ; RADIOTHERAPY
资助项目National Key Research and Development Program of China[2023YFE0104300] ; National Key Research and Development Program of China[2022YFC2304303] ; National Key Research and Development Program of China[2022YFC3401400] ; National Natural Science Foundation of China[32071385] ; Clinical Trial Ethics Committee of Shanghai Pudong Hospital[2022-RS-XM-01]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001331434300001
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/313796]  
专题新药研究国家重点实验室
通讯作者Li, Yaping; Zhang, Zhiwen
作者单位1.Univ Auckland, Auckland 1142, New Zealand
2.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
3.Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China
4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
5.Fudan Univ, Shanghai Pudong Hosp, Pudong Med Ctr, Dept Breast Surg, Shanghai 201399, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Yao,Li, Yongping,Xie, Honglei,et al. Biomimetic nanoreactor of catalase and nitric oxide enhance peroxynitrite generation for radiosensitization[J]. NANO TODAY,2024,59:12.
APA Wu, Yao.,Li, Yongping.,Xie, Honglei.,Zhang, Yichen.,Bao, Xinyue.,...&Zhang, Zhiwen.(2024).Biomimetic nanoreactor of catalase and nitric oxide enhance peroxynitrite generation for radiosensitization.NANO TODAY,59,12.
MLA Wu, Yao,et al."Biomimetic nanoreactor of catalase and nitric oxide enhance peroxynitrite generation for radiosensitization".NANO TODAY 59(2024):12.

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来源：上海药物研究所

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