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Nanotechnology used for siRNA delivery for the treatment of neurodegenerative diseases: Focusing on Alzheimer's disease and Parkinson's disease

文献类型：期刊论文

作者Li, Yan4,5; Zhang, Jiahui3; Ma, Boqin2; Yu, Wenjun4; Xu, Meixia4,5; Luan, Weijing4,5; Yu, Qinglong4,5; Zhang, Li4,5; Rong, Rong4,5; Fu, Yuanlei4,5
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
出版日期2024-12-05
卷号666页码:15
关键词Neurodegenerative diseases Brain drug delivery Therapeutic drug Small interfering RNA Nanotechnology
ISSN号0378-5173
DOI10.1016/j.ijpharm.2024.124786
通讯作者Rong, Rong(rrong@yimm.ac.cn) ; Fu, Yuanlei(ylfu@yimm.ac.cn) ; Cao, Haiqiang(caohaiqiang1@simm.ac.cn)
英文摘要Neurodegenerative diseases (ND) are often accompanied by dementia, motor dysfunction, or disability. Caring for these patients imposes a significant psychological and financial burden on families. Until now, there are no effective methods for the treatment of NDs. Among them, Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common. Recently, studies have revealed that the overexpression of certain genes may be linked to the occurrence of AD and PD. Small interfering RNAs (siRNAs) are a powerful tool for gene silencing because they can specifically bind to and cleave target mRNA. However, the intrinsic properties of naked siRNA and various physiological barriers limit the application of siRNA in the brain. Nanotechnology is a promising option for addressing these issues. Nanoparticles are not only able to protect siRNA from degradation but also have the advantage of crossing various physiological barriers to reach the brain target of siRNA. In this review, we aim to introduce diverse nanotechnology used for delivering siRNA to treat AD and PD. Finally, we will briefly discuss our perspectives on this promising field.
WOS关键词BLOOD-BRAIN-BARRIER ; LIPID NANOPARTICLES ; DRUG-DELIVERY ; TRANSFECTION EFFICIENCY ; CHITOSAN NANOPARTICLES ; MAGNETIC NANOPARTICLES ; GENE DELIVERY ; A-BETA ; PEPTIDE ; TAU
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001334105100001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/313808]  
专题中国科学院上海药物研究所
通讯作者Rong, Rong; Fu, Yuanlei; Cao, Haiqiang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Anhui Univ Chinese Med, Sch Pharm, Hefei 230012, Peoples R China
3.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
5.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yan,Zhang, Jiahui,Ma, Boqin,et al. Nanotechnology used for siRNA delivery for the treatment of neurodegenerative diseases: Focusing on Alzheimer's disease and Parkinson's disease[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2024,666:15.
APA Li, Yan.,Zhang, Jiahui.,Ma, Boqin.,Yu, Wenjun.,Xu, Meixia.,...&Cao, Haiqiang.(2024).Nanotechnology used for siRNA delivery for the treatment of neurodegenerative diseases: Focusing on Alzheimer's disease and Parkinson's disease.INTERNATIONAL JOURNAL OF PHARMACEUTICS,666,15.
MLA Li, Yan,et al."Nanotechnology used for siRNA delivery for the treatment of neurodegenerative diseases: Focusing on Alzheimer's disease and Parkinson's disease".INTERNATIONAL JOURNAL OF PHARMACEUTICS 666(2024):15.

入库方式： OAI收割

来源：上海药物研究所

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