中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Mobilizing STING Pathway via a Cationic Liposome to Enhance Doxorubicin-Induced Antitumor Immunity

文献类型：期刊论文

作者Liu, Xiaochen3,4,5; Zhao, Zhiwen3,4,5; Xu, Xiaoxuan3,4,5; Yi, Wenzhe3,4,5; Yan, Dan3,4,5; Wang, Dangge2; Li, Yaping1,3,4,5
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2024-10-08
页码12
关键词biological barriers cancer immunotherapy cationic liposomes immunogenic cell death STING pathway
ISSN号1616-301X
DOI10.1002/adfm.202416406
通讯作者Wang, Dangge(dg_wang@sjtu.edu.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要The efficacy of anthracycline, such as doxorubicin (DOX), is facilitated by cancer cell-intrinsic type I interferon (IFN-I) signaling through the induction of immune responses. However, weak and chronic IFN-I responses from rounds of chemotherapy lead to resistance against DNA damage and acquired resistance to the therapy. An exogenous supply of IFN-I can improve the chemotherapeutic responses. Herein, a library of cationic liposomes is developed for the optimization of 1, 2-dioleoyl-3-trimethylammonium-propane (DOTAP) proportions to enhance the lysosome escape and tumor distribution of the stimulator of interferon genes (STING) agonist 2 ',3 '-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) and DOX. The cationic liposomes with 8% DOTAP release cGAMP into the cytoplasm and increase the concentration of DOX in the tumor by 1.5 times compared with the free drug. Upon accumulation at the tumor site, the optimized liposomes induce immunogenic cell death (ICD) and stimulate the STING signaling, thereby improving the production of endogenous IFN-I and promoting dendritic cell maturation to mobilize T cell immunity. The tumor growth inhibition rate is 86%, and the median survival time is 1.6-fold prolonged. This study offers a strategy to enhance the DOX-induced immune response by activating the STING pathway to supply IFN-I.
WOS关键词CANCER ; CELLS
资助项目National Key R&D Program of China ; National Facility for Protein Science in Shanghai ; National Natural Science Foundation of China[32170935] ; National Natural Science Foundation of China[31930066] ; Shanghai Rising-star Program[23QA1411200] ; [2022YFC3401404]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:001330792200001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/313966]  
专题新药研究国家重点实验室
通讯作者Wang, Dangge; Li, Yaping
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264000, Shandong, Peoples R China
2.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Precis Res Ctr Refractory Dis, Sch Med, Shanghai 201620, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Xiaochen,Zhao, Zhiwen,Xu, Xiaoxuan,et al. Mobilizing STING Pathway via a Cationic Liposome to Enhance Doxorubicin-Induced Antitumor Immunity[J]. ADVANCED FUNCTIONAL MATERIALS,2024:12.
APA Liu, Xiaochen.,Zhao, Zhiwen.,Xu, Xiaoxuan.,Yi, Wenzhe.,Yan, Dan.,...&Li, Yaping.(2024).Mobilizing STING Pathway via a Cationic Liposome to Enhance Doxorubicin-Induced Antitumor Immunity.ADVANCED FUNCTIONAL MATERIALS,12.
MLA Liu, Xiaochen,et al."Mobilizing STING Pathway via a Cationic Liposome to Enhance Doxorubicin-Induced Antitumor Immunity".ADVANCED FUNCTIONAL MATERIALS (2024):12.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。