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Immunosuppressive Breviane Spiroditerpenoids from Penicillium bialowiezense Isolated from a Medicinal Plant

文献类型：期刊论文

作者Chen, Shu-Shuai3; Gao, Yuan2,3; Chen, Li3; Tong, Xiao3; Wu, Pei-Qian3; Huang, Yi3; He, Shi-Jun1; Yue, Jian-Min3; Zhou, Bin3
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2024-10-09
卷号87期号:10页码:2468-2477
ISSN号0163-3864
DOI10.1021/acs.jnatprod.4c00782
通讯作者He, Shi-Jun(heshijun@shutcm.edu.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) ; Zhou, Bin(zbbrush@simm.ac.cn)
英文摘要Breviane spiroditerpenoids are a small group of structurally interesting and complex meroterpenoids. This work focused on an endophytic fungus Penicillium bialowiezense ZBWPQ-27 that was isolated from a medicinal plant Euphorbia neriifolia, leading to the isolation of 15 breviane spiroditerpenoids with four types of polycyclic systems (1-6 and 9-17), and two new carotane sesquiterpenoids (7 and 8). The structures including absolute configurations of the new compounds 1-8 were elucidated by spectroscopic data analysis and electronic circular dichroism (ECD) calculations. In addition, the misassigned NMR data of several resonances of the 5-methyl-TAL motif (E ring) in those of known brevianes (9-15) were corrected by spectroscopic data analysis. Biological tests revealed that brevianes with the type A ring system (6/6/6/5/6) showed moderate to significant immunosuppressive activities, and compound 11 displayed the most potent inhibitory activities against concanavalin A (ConA)-induced T cell proliferation (IC50 4.1 +/- 0.2 mu M) and lipopolysaccharide (LPS)-induced B cell proliferation (IC50 4.6 +/- 0.2 mu M), with good SI values of 28 +/- 2 and 25 +/- 4, respectively.
WOS关键词ASCOMYCETE
资助项目National Natural Science Foundation[82322064] ; Youth Innovation Promotion Association of CAS[2022283]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001335795600001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/313969]  
专题新药研究国家重点实验室
通讯作者He, Shi-Jun; Yue, Jian-Min; Zhou, Bin
作者单位1.Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai 201203, Peoples R China
2.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Shu-Shuai,Gao, Yuan,Chen, Li,et al. Immunosuppressive Breviane Spiroditerpenoids from Penicillium bialowiezense Isolated from a Medicinal Plant[J]. JOURNAL OF NATURAL PRODUCTS,2024,87(10):2468-2477.
APA Chen, Shu-Shuai.,Gao, Yuan.,Chen, Li.,Tong, Xiao.,Wu, Pei-Qian.,...&Zhou, Bin.(2024).Immunosuppressive Breviane Spiroditerpenoids from Penicillium bialowiezense Isolated from a Medicinal Plant.JOURNAL OF NATURAL PRODUCTS,87(10),2468-2477.
MLA Chen, Shu-Shuai,et al."Immunosuppressive Breviane Spiroditerpenoids from Penicillium bialowiezense Isolated from a Medicinal Plant".JOURNAL OF NATURAL PRODUCTS 87.10(2024):2468-2477.

入库方式： OAI收割

来源：上海药物研究所

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