Chemical profiling and comparative analysis of different parts of Asarum heterotropoides using SPME-GC-QTOF-MS and LC- Orbitrap-MS
文献类型：期刊论文
| 作者 | Hu, Yun-shu3; Zhang, Jian-qing3; Xu, Meng3; Yang, Huan-ya3; Liu, Chun-xiang3; Li, Yun3; Bi, Qi-rui3; Yang, Yang1; Chen, Qin-hua1; Guo, De-an2,3
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| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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| 出版日期 | 2025 |
| 卷号 | 252页码:9 |
| 关键词 | Asari radix et rhizoma A. heterotropoides SPME-GC-MS LC-Orbitrap-MS |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2024.116502 |
| 通讯作者 | Chen, Qin-hua(daguo@simm.ac.cn) ; Guo, De-an(daguo@simm.ac.cn) |
| 英文摘要 | Asari radix et rhizoma is the sole plant from the Aristolochiaceae family officially sanctioned for medicinal in China, primarily employed for treating colds and headaches, and is widely utilized in clinical practice. Initially, the entire plant was specified for medicinal use, but since 2005, the authorized part has been restricted to the roots and rhizomes. The chemical constituents are directly linked to its efficacy and safety, yet a comparative analysis of the chemical profiles between the overground and underground parts has not been reported. This paper represents the first comparative study of the chemical constituents in the two parts, achieved through the synergistic application of solid phase micro extraction coupled with gas chromatography mass spectrometry (SPME-GC-MS) and liquid chromatography Orbitrap MS (LC-Orbitrap-MS). Using SPME-GC-MS, 51 constituents were identified from both parts, with 89 % being shared components, indicating a close similarity in their volatile compositions. Through LC-Orbitrap-MS, 308 constituents were identified, sharing 76 % commonality, revealing a more pronounced disparity in non-volatile components. Plant metabolomics screening pinpointed 8 volatile and 14 non-volatile components capable of distinguishing the two parts, with the latter being more stable and thus better suited as markers for differentiation. This research furnishes a scientific rationale for selecting distinct parts of Asari radix et rhizoma and for implementing monitoring strategies in clinical application. |
| WOS关键词 | ESSENTIAL OIL ; RADIX ; RHIZOMA ; IDENTIFICATION |
| 资助项目 | Sanming Project of Medicine in Shenzhen[SZZYSM202106004] ; SIMM-National Engineering Research Center of TCM Standardization Technology independent Research Program, Science and Technology Major Project of Inner Mongolia[2021ZD0017] ; National Natural Science Foundation of China[82104385] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001336159800001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313972]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Qin-hua; Guo, De-an |
| 作者单位 | 1.Shenzhen Baoan Authent TCM Therapy Hosp, Key Lab TCM Clin Pharm, Shenzhen 518000, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Res Ctr TCM Standardizat Technol, Haike Rd 501, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Yun-shu,Zhang, Jian-qing,Xu, Meng,et al. Chemical profiling and comparative analysis of different parts of Asarum heterotropoides using SPME-GC-QTOF-MS and LC- Orbitrap-MS[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2025,252:9. |
| APA | Hu, Yun-shu.,Zhang, Jian-qing.,Xu, Meng.,Yang, Huan-ya.,Liu, Chun-xiang.,...&Guo, De-an.(2025).Chemical profiling and comparative analysis of different parts of Asarum heterotropoides using SPME-GC-QTOF-MS and LC- Orbitrap-MS.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,252,9. |
| MLA | Hu, Yun-shu,et al."Chemical profiling and comparative analysis of different parts of Asarum heterotropoides using SPME-GC-QTOF-MS and LC- Orbitrap-MS".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 252(2025):9. |
入库方式： OAI收割
来源：上海药物研究所
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