Germacrane-type sesquiterpenes from Artemisia atrovirens and their anti-inflammatory activity
文献类型：期刊论文
| 作者 | Tang, Chunping3,4 ; Zheng, Yongzhe2,4; Shao, Zhengguang2,4; Ke, Chang-Qiang3,4; Feng, Zheling3,4; Ye, Yang1,2,3,4
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 179页码:11 |
| 关键词 | Artemisia atrovirens Atrovirenolides C -I Atrovirenoic acid G Diatrovirenolides A -B DFT NMR calculation TDDFT ECD calculation |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2024.106241 |
| 通讯作者 | Tang, Chunping(yye@simm.ac.cn) |
| 英文摘要 | Artemisia plants are well-known for their abundant sesquiterpene compounds, which encompass various structural types and exhibit a range of biological activities. In this study, a systematic investigation of Artemisia atrovirens revealed the presence of germacrane-type sesquiterpenes for the first time. This included the discovery of 10 new compounds and three known analogues, among which were two rare dimeric germacrane-type compounds. Their structures were fully characterized through a comprehensive analysis involving MS, IR, 1Dand 2D-NMR spectroscopic data, single crystal X-ray diffraction, density functional theory (DFT) NMR calculations, and time-dependent DFT electronic circular dichroism (TDDFT ECD) calculations. Furthermore, all isolated compounds were evaluated for their anti-inflammatory activity in LPS-stimulated RAW 264.7 murine macrophages. Compound 10 demonstrated a potent inhibitory effect on NO production, with an IC50 value of 4.01 +/- 0.09 mu M. This study highlights the diverse chemical repertoire of Artemisia species and underscores their potential in drug discovery and development. |
| WOS关键词 | LACTONES ; GENUS |
| 资助项目 | National Key Research and Development Program Strategic Scientific and Technological Innovation Cooperation Key Project[2022YFE0203600] ; Key-Area Research and Development Program of Guangdong Province[2020B0303070002] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001335219500001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313984]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Tang, Chunping |
| 作者单位 | 1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, China Serbia Belt & Rd Joint Lab Nat Prod & Drug D, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Chunping,Zheng, Yongzhe,Shao, Zhengguang,et al. Germacrane-type sesquiterpenes from Artemisia atrovirens and their anti-inflammatory activity[J]. FITOTERAPIA,2024,179:11. |
| APA | Tang, Chunping,Zheng, Yongzhe,Shao, Zhengguang,Ke, Chang-Qiang,Feng, Zheling,&Ye, Yang.(2024).Germacrane-type sesquiterpenes from Artemisia atrovirens and their anti-inflammatory activity.FITOTERAPIA,179,11. |
| MLA | Tang, Chunping,et al."Germacrane-type sesquiterpenes from Artemisia atrovirens and their anti-inflammatory activity".FITOTERAPIA 179(2024):11. |
入库方式： OAI收割
来源：上海药物研究所
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