Precision Photothermal Therapy at Mild Temperature: NIR-II Imaging-Guided, H2O2-Responsive Stealth Nanobomb
文献类型：期刊论文
| 作者 | Ma, Gongcheng6; Ding, Qihang5; Wang, Yue4; Zhang, Zhiwei3,4; Zhang, Yuding4; Shi, Hui2; Cai, Lintao1,4; Gong, Ping4; Zhang, Pengfei4; Cheng, Zhen2 |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2024-10-10 |
| 页码 | 9 |
| 关键词 | aggregation-induced emission carbon monoxide heat shock proteins mild-temperature photothermal therapy NIR-II imaging |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.202402767 |
| 通讯作者 | Gong, Ping(ping.gong@siat.ac.cn) ; Zhang, Pengfei(pf.zhang@siat.ac.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) ; Kim, Jong Seung(jongskim@korea.ac.kr) |
| 英文摘要 | The therapeutic efficacy of photothermal therapy (PTT) under mild temperatures (<45 degrees C) is hindered as cancer cells can activate heat shock proteins (HSPs) to mend fever-type cellular damage swiftly. The previous attempt fabricated first-generation nanobombs (nanobomb1G) by self-assembly of polymeric NIR-II AIEgens and carbon monoxide (CO) carrier polymer mPEG(CO) to inhibit the expression of HSPs after intratumor injection. A new generation nanobomb (Stealth NanoBomb (SNB)) is developed by self-assembling small molecular NIR-II AIEgens with CO carrier polymer PLGA(CO) coated by PEG-lipid. This design allows for intravenous administration, enabling the SNB to circulate safely in the bloodstream and selectively target cancer cells. Upon accumulation in tumors, the SNB releases CO to effectively suppress HSP expression, enhancing the therapeutic efficacy of mild-temperature PTT. Compared to the previous generation, the SNB offers a safer, more stable, and more efficient CO gas/drug co-delivery system for cancer treatment. This work represents a significant advancement in PTT, providing a promising strategy for enhanced antitumor therapy with reduced systemic toxicity. |
| WOS关键词 | POLYMER HYBRID NANOPARTICLES ; DRUG-DELIVERY ; LIGHT |
| 资助项目 | National Key R&D Programs (China)[2021YFA0910001] ; National Key R&D Programs (China)[2023YFA0915402] ; Guangdong Provincial Key Area RD Program[2020B1111540001] ; Shenzhen Science and Technology Program[KQTD20210811090115019] ; Shenzhen Basic Research (key project)(China)[JCYJ20210324120011030] ; Shenzhen Basic Research (key project)(China)[JCYJ20210324115804013] ; Shenzhen Basic Research (key project)(China)[JCYJ20200109114616534] ; Major Instrumentation Development Program of the Chinese Academy of Sciences[ZDKYYQ20220008] ; Shenzhen-Macao Technology Plan[SGDX2020110309280301] ; National Natural Science Foundation of China[22105057] ; National Natural Science Foundation of China[81901906] ; National Natural Science Foundation of China[32000982] ; Technological Cooperation Projects (China)[2020A0505100047] ; Guangdong Basic and Applied Basic Research Fund Project (China)[2019A1515110222] ; Guangdong Basic and Applied Basic Research Fund Project (China)[2021A1515110699] ; Zhuhai Innovation and Entrepreneurship Team Project[ZH01110405180056PWC] ; National Natural Science Foundation of China (NSFC)[U2267221] ; Shandong Laboratory Program[SYS202205] ; National Research Foundation of Korea (CRI)[2018R1A3B1052702] |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001335928000001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/313993]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Gong, Ping; Zhang, Pengfei; Cheng, Zhen; Kim, Jong Seung |
| 作者单位 | 1.Sino Euro Ctr Biomed & Hlth, Shenzhen 518024, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shenzhen Inst Adv Technol, CAS Key Lab Hlth Informat, Guangdong Key Lab Nanomed,CAS HK Joint Lab Biomat,, Shenzhen 518055, Peoples R China 5.Korea Univ, Dept Chem, Seoul 02841, South Korea 6.Xinxiang Med Univ, Sch Life Sci & Technol, Xinxiang 453003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Gongcheng,Ding, Qihang,Wang, Yue,et al. Precision Photothermal Therapy at Mild Temperature: NIR-II Imaging-Guided, H2O2-Responsive Stealth Nanobomb[J]. ADVANCED HEALTHCARE MATERIALS,2024:9. |
| APA | Ma, Gongcheng.,Ding, Qihang.,Wang, Yue.,Zhang, Zhiwei.,Zhang, Yuding.,...&Kim, Jong Seung.(2024).Precision Photothermal Therapy at Mild Temperature: NIR-II Imaging-Guided, H2O2-Responsive Stealth Nanobomb.ADVANCED HEALTHCARE MATERIALS,9. |
| MLA | Ma, Gongcheng,et al."Precision Photothermal Therapy at Mild Temperature: NIR-II Imaging-Guided, H2O2-Responsive Stealth Nanobomb".ADVANCED HEALTHCARE MATERIALS (2024):9. |
入库方式： OAI收割
来源：上海药物研究所
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