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Macrocyclic anti-inflammatory diterpenes from the South China Sea soft coral Sinularia erecta and their isolation by combined column chromatography

文献类型：期刊论文

作者Li, Song-Wei4; Cuadrado, Cristina3; Liu, Jiao2; Li, Heng2; Tang, Wei2; Daranas, Antonio Hernandez3; Guo, Yue-Wei1,4
刊名JOURNAL OF CHROMATOGRAPHY A
出版日期2024-11-08
卷号1736页码:11
关键词Marine natural products Soft coral Sinularia erecta Column chromatography Quantum mechanical calculation Anti-inflammatory
ISSN号0021-9673
DOI10.1016/j.chroma.2024.465416
通讯作者Tang, Wei(tangwei@simm.ac.cn) ; Daranas, Antonio Hernandez(adaranas@ipna.csic.es) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Eleven new macrocyclic casbane-type diterpenes, namely sinueracasbanones E-O (1-11), have been isolated from the South China Sea soft coral Sinularia erecta using combined column chromatography. The structures of new compounds were elucidated by extensive spectroscopic data analysis, the modified Mosher's method, X-ray diffraction analysis and quantum mechanical calculation methods. In bioassay, compounds 2, 5, 10 and 11 displayed interesting anti-inflammatory activities by the inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha protein release with half maximal inhibitory concentration (IC50) values of 15.6, 7.1, 13.7 and 6.6 mu M, respectively.
资助项目National Key Research and Development Program of China[2022YFC2804100] ; Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[82304375] ; Shandong Laboratory Program[SYS202205] ; Ministerio de Ciencia, Innovacion y Universidades of Spanish Gobernment MICINN[PID2019-109476RB-C21] ; Agencia Canaria de Investigacion, Innovacion y Sociedad de la Informacion ACIISI-FEDER[2021010118] ; ACIISI ; FSE ; Cabildo de Tenerife, under the TFinnova by MEDI[2021010118] ; FDCAN funds
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001335843600001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/313996]  
专题新药研究国家重点实验室
通讯作者Tang, Wei; Daranas, Antonio Hernandez; Guo, Yue-Wei
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
3.CSIC, IPNA, San Cristobal la Laguna 38206, Tenerife, Spain
4.Shanghai Univ, Sch Med, 99 Shangda Rd, Shanghai 200444, Peoples R China
推荐引用方式
GB/T 7714		 Li, Song-Wei,Cuadrado, Cristina,Liu, Jiao,et al. Macrocyclic anti-inflammatory diterpenes from the South China Sea soft coral Sinularia erecta and their isolation by combined column chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2024,1736:11.
APA Li, Song-Wei.,Cuadrado, Cristina.,Liu, Jiao.,Li, Heng.,Tang, Wei.,...&Guo, Yue-Wei.(2024).Macrocyclic anti-inflammatory diterpenes from the South China Sea soft coral Sinularia erecta and their isolation by combined column chromatography.JOURNAL OF CHROMATOGRAPHY A,1736,11.
MLA Li, Song-Wei,et al."Macrocyclic anti-inflammatory diterpenes from the South China Sea soft coral Sinularia erecta and their isolation by combined column chromatography".JOURNAL OF CHROMATOGRAPHY A 1736(2024):11.

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来源：上海药物研究所

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