Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets
文献类型：期刊论文
| 作者 | Sun, Meng3; Chen, Zhen-ru1,2; Ding, Hui-juan3; Feng, Jing1,2 |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2024-10-18 |
| 页码 | 15 |
| 关键词 | itch GPCRs Mrgprs TRP channels cytokines neuroimmune |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-024-01400-x |
| 通讯作者 | Feng, Jing(fengjing@simm.ac.cn) |
| 英文摘要 | Itch is an uncomfortable feeling that evokes a desire to scratch. This protective reflex can effectively eliminate parasites that invade the skin. When itchy skin becomes severe or lasts for more than six weeks, it has deleterious effects on both quality of life and productivity. Despite decades of research, the complete molecular and cellular coding of chronic itch remains elusive. This persistent condition often defies treatment, including with antihistamines, and poses a significant societal challenge. Obtaining pathophysiological insights into the generation of chronic itch is essential for understanding its mechanisms and the development of innovative anti-itch medications. In this review we provide a systematic overview of the recent advancement in itch research, alongside the progress made in drug discovery within this field. We have examined the diversity and complexity of the classification and mechanisms underlying the complex sensation of itch. We have also delved into recent advancements in the field of itch mechanism research and how these findings hold potential for the development of new itch treatment medications. But the treatment of clinical itch symptoms still faces significant challenges. Future research needs to continue to delve deeper, not only to discover more itch-related pathways but also to explore how to improve treatment efficacy through multitarget or combination therapy. |
| WOS关键词 | ATOPIC-DERMATITIS ; DOUBLE-BLIND ; SPINAL-CORD ; TACROLIMUS OINTMENT ; SENSORY NEURONS ; MURINE MODEL ; ACTIVATION ; RECEPTORS ; TRANSMISSION ; INVOLVEMENT |
| 资助项目 | National Natural Science Foundation of China[82171214] ; National Natural Science Foundation of China[32241003] ; Shanghai Municipal Natural Science Foundation[23ZR1474500] ; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001335329500001 |
| 出版者 | NATURE PUBL GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314002]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Feng, Jing |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Meng,Chen, Zhen-ru,Ding, Hui-juan,et al. Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets[J]. ACTA PHARMACOLOGICA SINICA,2024:15. |
| APA | Sun, Meng,Chen, Zhen-ru,Ding, Hui-juan,&Feng, Jing.(2024).Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets.ACTA PHARMACOLOGICA SINICA,15. |
| MLA | Sun, Meng,et al."Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets".ACTA PHARMACOLOGICA SINICA (2024):15. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。