Benzofurans and dibenzofurans from galls on twigs of the endangered Chinese endemic tree Parrotia subaequalis and their inhibitory properties against Staphylococcus aureus and ATP-citrate lyase
文献类型：期刊论文
| 作者 | Zhou, Peng-Jun3,4; Wu, Xi-Ying3,4; Zhao, Ze-Yu3,4; Zang, Yi2 ; Sun, Zhong-Shuai4; Li, Yue-Ling4; Li, Na4; Xiong, Juan3; Choo, Yeun-Mun1; Jin, Ze-Xin4
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2025 |
| 卷号 | 229页码:9 |
| 关键词 | Parrotia subaequalis Hamamelidaceae Gall Phytoalexins Benzofuran Dibenzofuran Staphylococcus aureus ATP-Citrate lyase |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2024.114309 |
| 通讯作者 | Hu, Jin-Feng(jfhu@tzc.edu.cn) |
| 英文摘要 | Parrotia subaequalis, an endangered Tertiary relict tree native to China and a member of the Hamamelidaceae family, is one of several host plant species in this family that exhibit unique ecological habits, such as gall formation. Tree galls are the results of complex interactions between gall-inducing insects and their host plant organs. The formation of galls may serve to protect other regions of the plant from potential damage, often through the production of phytoalexins. In this study, a preliminary investigation was carried out on the metabolites of the 90% MeOH extract derived from the closed spherical galls on the twigs of P. subaequalis. Consequently, nine previously undescribed benzofuran-type and dibenzofuran-type phytoalexins (parrotiagallols A-I, 1-9, respectively) were isolated and characterized, along with several known miscellaneous metabolites (10-17). Their chemical structures and absolute configurations were elucidated using spectroscopic methods, a combination of calculated and experimental electronic circular dichroism data, and single crystal X-ray diffraction analyses. Among these compounds, 1 and 2 are identified as neolignan derivatives, while compounds 3-5 are classified as 9,10-dinorneolignans. Compound 6 represents a rare 2,3-seco-neolignan, and compounds 7-9 are dihydroxy-dimethyl-dibenzofuran derivatives. Parrotiagallol A (1) showed considerable antibacterial activity against Staphylococcus aureus, with an MIC value of 14 mu M. Additionally, parrotiagallol E (5) and methyl gallate (17) exhibited inhibitory effects against ATP-citrate lyase (ACL), a potential therapeutic target for hyperlipidemia, with IC50 values of 5.1 and 9.8 mu M, respectively. The findings underscore that galls not only serve as physical defense barriers but also benefit from the chemical defense system of the host plants. These insights provide avenues for exploring potential new therapeutic agents for S. aureus infections and ACL-related diseases, while also promoting scientific conservation strategies for P. subaequalis. |
| WOS关键词 | SESQUITERPENE LACTONES ; NEOLIGNANS ; CONSTITUENTS ; DERIVATIVES ; DISCOVERY |
| 资助项目 | National Natural Science Foundation of China[21937002] ; Zhejiang Provincial Natural Science Foundation of China[LY23H300001] ; Zhejiang Provincial Science and Technology Plan Project[LGN21H300001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001339755100001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314017]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hu, Jin-Feng |
| 作者单位 | 1.Univ Malaya, Fac Sci, Chem Dept, Kuala Lumpur 50603, Malaysia 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China 4.Taizhou Univ, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Plant Evolutionary Ecol & Co, Taizhou 318000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Peng-Jun,Wu, Xi-Ying,Zhao, Ze-Yu,et al. Benzofurans and dibenzofurans from galls on twigs of the endangered Chinese endemic tree Parrotia subaequalis and their inhibitory properties against Staphylococcus aureus and ATP-citrate lyase[J]. PHYTOCHEMISTRY,2025,229:9. |
| APA | Zhou, Peng-Jun.,Wu, Xi-Ying.,Zhao, Ze-Yu.,Zang, Yi.,Sun, Zhong-Shuai.,...&Hu, Jin-Feng.(2025).Benzofurans and dibenzofurans from galls on twigs of the endangered Chinese endemic tree Parrotia subaequalis and their inhibitory properties against Staphylococcus aureus and ATP-citrate lyase.PHYTOCHEMISTRY,229,9. |
| MLA | Zhou, Peng-Jun,et al."Benzofurans and dibenzofurans from galls on twigs of the endangered Chinese endemic tree Parrotia subaequalis and their inhibitory properties against Staphylococcus aureus and ATP-citrate lyase".PHYTOCHEMISTRY 229(2025):9. |
入库方式： OAI收割
来源：上海药物研究所
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