Aspongpyridiniums A- J, amino acid-derived pyridinium salts from insect species Aspongopus chinensis
文献类型：期刊论文
| 作者 | Nie, Jinchun1,2; Guo, Shuang1; Wang, Didi1; Li, Zhenwei1; Zhang, Daidi1; Li, Wei1,2; Guo, De-an1,2
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2025 |
| 卷号 | 229页码:8 |
| 关键词 | Aspongopus chinensis Amino acid-derived pyridinium salt ECD calculation alpha-glucosidase inhibitory activity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2024.114299 |
| 通讯作者 | Li, Wei(liwei1@simm.ac.cn) ; Guo, De-an(daguo@simm.ac.cn) |
| 英文摘要 | Aspongpyridiniums A-J (1-10), ten previously undescribed amino acid-derived pyridinium salts were isolated and identified from the n-BuOH fraction of the 50% MeOH extract of insect species Aspongopus chinensis, wellknown for its use in traditional Chinese medicine for the treatment of pain, indigestion and kidney diseases. Their structures were determined by extensive spectroscopic data as well as electronic circular dichroism calculations and comparisons. Aspongpyridiniums A-J are structurally characterized by a unique 1,3,4-trisubstituted pyridinium skeleton with a variable functional group derived from an amino acid unit. In bioassays, Compounds 5 and 10 exhibited certain inhibitory activities against alpha-glucosidase, while 1-10 showed moderate to weak acetylcholinesterase inhibitory effects. |
| 资助项目 | Key Program of National Natural Science Foundation of China[82130111] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001344319300001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314023]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Wei; Guo, De-an |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 2.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nie, Jinchun,Guo, Shuang,Wang, Didi,et al. Aspongpyridiniums A- J, amino acid-derived pyridinium salts from insect species Aspongopus chinensis[J]. PHYTOCHEMISTRY,2025,229:8. |
| APA | Nie, Jinchun.,Guo, Shuang.,Wang, Didi.,Li, Zhenwei.,Zhang, Daidi.,...&Guo, De-an.(2025).Aspongpyridiniums A- J, amino acid-derived pyridinium salts from insect species Aspongopus chinensis.PHYTOCHEMISTRY,229,8. |
| MLA | Nie, Jinchun,et al."Aspongpyridiniums A- J, amino acid-derived pyridinium salts from insect species Aspongopus chinensis".PHYTOCHEMISTRY 229(2025):8. |
入库方式： OAI收割
来源：上海药物研究所
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