Highly oxygenated clerodane furanoditerpenoids from the leaves and twigs of Croton yunnanensis
文献类型：期刊论文
| 作者 | Wang, Didi1,2; Mei, Fang1; Nie, Jinchun1; Li, Zhenwei1; Zhang, Daidi1; Guo, Dean1,2 ; Li, Wei1,2
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| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
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| 出版日期 | 2024-10-01 |
| 卷号 | 22期号:10页码:945-954 |
| 关键词 | Croton yunnanensis Euphorbiaceae Clerodane furanoditerpenoid NO inhibitory activity |
| ISSN号 | 2095-6975 |
| DOI | 10.1016/S1875-5364(24)60722-3 |
| 通讯作者 | Guo, Dean(daguo@simm.ac.cn) ; Li, Wei(liwei1@simm.ac.cn) |
| 英文摘要 | The phytochemical investigation of the leaves and twigs of Croton yunnanensis resulted in the isolation of eight new clerodane furanoditerpenoids, named croyunfuranoids A-H (1-8), along with three known analogs (9-11). The structures of these compounds were elucidated using spectroscopic analyses, and their absolute configurations were determined through a combination of electronic circular dichroism (ECD) calculations and single-crystal X-ray diffraction. Notably, Croyunfuranoid D (4) is identified as a rare 18,19-dinor-clerodane diterpenoid. Additionally, the structure of a previously reported diterpenoid, crotonyunnan B, was revised. All isolated compounds were evaluated for their inhibitory activities on nitric oxide (NO) production in LPS-induced RAW 264.7 macrophages. Among them, compounds 5 and 6 demonstrated significant inhibitory effects, with IC50 values of 20.33 +/- 2.31 and 22.80 +/- 1.31 mu mol |
| WOS关键词 | DITERPENOIDS |
| 资助项目 | National Natural Science Foundation of China[82104020] ; National Natural Science Foundation of China[82130111] ; High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province[2021B0909050003] ; High-level New R&D Institute of Department of Science and Technology of Guangdong Province[2019B090904008] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001340065800001 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314026]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, Dean; Li, Wei |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 2.Guizhou Med Univ, Sch Pharm, Guiyang 550025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Didi,Mei, Fang,Nie, Jinchun,et al. Highly oxygenated clerodane furanoditerpenoids from the leaves and twigs of Croton yunnanensis[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2024,22(10):945-954. |
| APA | Wang, Didi.,Mei, Fang.,Nie, Jinchun.,Li, Zhenwei.,Zhang, Daidi.,...&Li, Wei.(2024).Highly oxygenated clerodane furanoditerpenoids from the leaves and twigs of Croton yunnanensis.CHINESE JOURNAL OF NATURAL MEDICINES,22(10),945-954. |
| MLA | Wang, Didi,et al."Highly oxygenated clerodane furanoditerpenoids from the leaves and twigs of Croton yunnanensis".CHINESE JOURNAL OF NATURAL MEDICINES 22.10(2024):945-954. |
入库方式： OAI收割
来源：上海药物研究所
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