Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling
文献类型：期刊论文
| 作者 | Lin, Feifei1,2 ; Hu, Yingchun1; Zhang, Yifan1; Zhao, Lijuan1; Zhong, Dafang1; Liu, Jia1,2
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| 出版日期 | 2024-10-01 |
| 卷号 | 25期号:20页码:13 |
| 关键词 | PBPK modeling piperine food-drug interaction |
| ISSN号 | 1661-6596 |
| DOI | 10.3390/ijms252010955 |
| 通讯作者 | Liu, Jia(jia.liu@simm.ac.cn) |
| 英文摘要 | Piperine has been reported to inhibit the enzyme activity of cytochrome P450 (CYP) 3A4. The aim of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model for piperine and to predict potential food-drug interactions (FDIs) between piperine and CYP3A4 substrate drugs using these models. The PBPK model for piperine was successfully developed and validated. Using this model, FDIs with ten CYP3A4 substrate drugs were simulated. The predicted area under the curve (AUC) ratios (with and without piperine, following a 7-day intake of 20 mg/day) for six drugs were found to exceed 1.25, with significant increases in AUC observed for ritonavir (31%), nifedipine (34%), cyclosporine (35%), triazolam (36%), alfentanil (39%), and simvastatin (59%) in humans. These findings suggest that caution should be exercised when consuming amounts of black pepper equivalent to a daily intake of 20 mg piperine during treatment with CYP3A4 substrate drugs, as it may significantly alter their pharmacokinetics. |
| WOS关键词 | ST-JOHNS-WORT ; INCORPORATING PATHOPHYSIOLOGICAL CHANGES ; HEART-FAILURE PATIENTS ; IN-VITRO ; GRAPEFRUIT JUICE ; TISSUE DISTRIBUTION ; ORAL AVAILABILITY ; P-GLYCOPROTEIN ; BLACK PEPPER ; PHARMACOKINETICS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001341518200001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314029]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Jia |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310058, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Feifei,Hu, Yingchun,Zhang, Yifan,et al. Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2024,25(20):13. |
| APA | Lin, Feifei,Hu, Yingchun,Zhang, Yifan,Zhao, Lijuan,Zhong, Dafang,&Liu, Jia.(2024).Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,25(20),13. |
| MLA | Lin, Feifei,et al."Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25.20(2024):13. |
入库方式： OAI收割
来源：上海药物研究所
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