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Citrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus

文献类型：期刊论文

作者Chen, Feifei5,6,7,8; Zhao, Qingmin5,6,8; Yang, Ziqiong5,6,8; Chen, Rongrong5,6,8; Pan, Huiwen5,6,8; Wang, Yanhui5,6,8; Liu, Huan5,6,8; Cao, Qiao8; Gan, Jianhua4; Liu, Xia3,6
刊名PLOS PATHOGENS
出版日期2024-07-01
卷号20期号:7页码:32
ISSN号1553-7366
DOI10.1371/journal.ppat.1012425
通讯作者Chen, Feifei(feifeichen@simm.ac.cn) ; Liang, Haihua(lianghh@sustech.edu.cn) ; Lan, Lefu(llan@ucas.ac.cn)
英文摘要Pathogenic bacteria's metabolic adaptation for survival and proliferation within hosts is a crucial aspect of bacterial pathogenesis. Here, we demonstrate that citrate, the first intermediate of the tricarboxylic acid (TCA) cycle, plays a key role as a regulator of gene expression in Staphylococcus aureus. We show that citrate activates the transcriptional regulator CcpE and thus modulates the expression of numerous genes involved in key cellular pathways such as central carbon metabolism, iron uptake and the synthesis and export of virulence factors. Citrate can also suppress the transcriptional regulatory activity of ferric uptake regulator. Moreover, we determined that accumulated intracellular citrate, partly through the activation of CcpE, decreases the pathogenic potential of S. aureus in animal infection models. Therefore, citrate plays a pivotal role in coordinating carbon metabolism, iron homeostasis, and bacterial pathogenicity at the transcriptional level in S. aureus, going beyond its established role as a TCA cycle intermediate.
WOS关键词GENE-EXPRESSION ; VIRULENCE DETERMINANTS ; CYCLE ACTIVITY ; GROWTH ; CODY ; FUR ; BIOSYNTHESIS ; COMPLEXITY ; CROSSTALK ; DRIVES
资助项目National Key Research and Development Program of China[2023YFD1800100] ; Hangzhou Institute for Advanced Study, UCAS[2023HIAS-V006] ; National Natural Science Foundation of China (NSFC)[32270184] ; National Natural Science Foundation of China (NSFC)[31700124]
WOS研究方向Microbiology ; Parasitology ; Virology
语种英语
WOS记录号WOS:001342372100003
出版者PUBLIC LIBRARY SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/314035]  
专题中国科学院上海药物研究所
通讯作者Chen, Feifei; Liang, Haihua; Lan, Lefu
作者单位1.Anhui Med Univ, Affiliated Hosp 1, Anhui Prov Key Lab Infect Dis, Hefei, Peoples R China
2.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
3.Naval Med Univ, Navy Med Ctr, Dept Diving & Hyperbar Med, Shanghai, Peoples R China
4.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci,State Key Lab Genet Engn, Shanghai, Peoples R China
5.Univ Chinese Acad Sci, Beijing, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
7.Northwest Univ, Coll Life Sci, Xian, Peoples R China
8.Univ Chinese Acad Sci, Sch Pharmaceut Sci & Technol, Hangzhou Inst Adv Study, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Feifei,Zhao, Qingmin,Yang, Ziqiong,et al. Citrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus[J]. PLOS PATHOGENS,2024,20(7):32.
APA Chen, Feifei.,Zhao, Qingmin.,Yang, Ziqiong.,Chen, Rongrong.,Pan, Huiwen.,...&Lan, Lefu.(2024).Citrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus.PLOS PATHOGENS,20(7),32.
MLA Chen, Feifei,et al."Citrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus".PLOS PATHOGENS 20.7(2024):32.

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来源：上海药物研究所

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