Salmonella Biomimetic Nanoparticles for Photothermal-Chemotherapy of Colorectal Cancer
文献类型：期刊论文
| 作者 | Liu, Ruichi4; Miao, Yunqiu4; Wen, Keyi4; Yang, Yang4; Xu, Dan4; Lu, Shengwei4; Liu, Ziyuan4; Qin, Huanlong4; Zhang, Xinxin2,3 ; Zhang, Yang1,4
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| 刊名 | NANO LETTERS
 |
| 出版日期 | 2024-10-21 |
| 卷号 | 24期号:43页码:13851-13860 |
| 关键词 | colorectal cancer salmonella biomimetic nanoparticles photothermal-chemotherapy tumor targeting tumor penetration |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.4c04609 |
| 通讯作者 | Qin, Huanlong(hlongqin@126.com) ; Zhang, Xinxin(xinxinzhang@simm.ac.cn) ; Zhang, Yang(zhangyang0202@tongji.edu.cn) |
| 英文摘要 | Nanomedicines have been widely used in colorectal cancer treatment, but their suboptimal targeting and deficient penetration capabilities remain obstacles in the delivery of therapeutics. In this study, inspired by the natural tumor tropism and intestinal invasion of Salmonella, we engineered highly biomimetic nanoparticles (SM-AuNRs) utilizing a Salmonella membrane to coat bacilliform Au nanorods. The engineered SM-AuNRs were able to mimic the germ's morphology and biological surface. SM-AuNRs containing the specific proteins inherited from the Salmonella membrane facilitated specific targeting and internalization into tumor cells. Meanwhile, SM-AuNRs with the rod-shaped morphology effectively traversed mucus barriers and tumor stroma. Due to the superior biological barrier penetrating and tumor targeting capabilities, doxorubicin-loaded SM-AuNRs with near-infrared laser irradiation displayed remarkable photothermal-chemotherapeutic antitumor effects in mouse orthotopic colorectal cancer models. Our findings pave the way for the design of bacteria-mimicking nanoparticles, presenting a promising avenue for the targeting and efficient treatment of colorectal cancer. |
| WOS关键词 | ENTERICA SEROVAR TYPHIMURIUM ; DRUG-DELIVERY ; APOPTOSIS ; BACTERIA ; PROTEIN ; CELLS |
| 资助项目 | National Natural Science Foundation of China[32271384] ; National Natural Science Foundation of China[82222066] ; National Natural Science Foundation of China[82104113] ; National Natural Science Foundation of China |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001340238600001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314038]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Qin, Huanlong; Zhang, Xinxin; Zhang, Yang |
| 作者单位 | 1.Tongji Univ, Shanghai Peoples Hosp 8, Sch Med, Dept Pharm, Shanghai 200235, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Tongji Univ, Shanghai Peoples Hosp 10, Nanomed & Intestinal Microecol Res Ctr, Sch Med, Shanghai 200072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ruichi,Miao, Yunqiu,Wen, Keyi,et al. Salmonella Biomimetic Nanoparticles for Photothermal-Chemotherapy of Colorectal Cancer[J]. NANO LETTERS,2024,24(43):13851-13860. |
| APA | Liu, Ruichi.,Miao, Yunqiu.,Wen, Keyi.,Yang, Yang.,Xu, Dan.,...&Zhang, Yang.(2024).Salmonella Biomimetic Nanoparticles for Photothermal-Chemotherapy of Colorectal Cancer.NANO LETTERS,24(43),13851-13860. |
| MLA | Liu, Ruichi,et al."Salmonella Biomimetic Nanoparticles for Photothermal-Chemotherapy of Colorectal Cancer".NANO LETTERS 24.43(2024):13851-13860. |
入库方式： OAI收割
来源：上海药物研究所
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