The role of dsRNA A-to-I editing catalyzed by ADAR family enzymes in the pathogeneses
文献类型：期刊论文
| 作者 | Liu, Wanqing9; Wu, Yufan9; Zhang, Tong9; Sun, Xiaobo5,6,7,8; Guo, Dean2,3,4 ; Yang, Zizhao1,5,6,7,8,9
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| 刊名 | RNA BIOLOGY
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| 出版日期 | 2024-12-31 |
| 卷号 | 21期号:1页码:52-69 |
| 关键词 | Double Stranded RNA (dsRNA) Adenosine-to-Inosine (A-to-I) Editing Adenosine Deaminases (ADAR) Enzyme Pathogenesis RNA Modification Tumorigenicity |
| ISSN号 | 1547-6286 |
| DOI | 10.1080/15476286.2024.2414156 |
| 通讯作者 | Guo, Dean(daguo@simm.ac.cn) ; Yang, Zizhao(zzyang@shutcm.edu.cn) |
| 英文摘要 | The process of adenosine deaminase (ADAR)-catalyzed double-stranded RNA (dsRNA) Adenosine-to-Inosine (A-to-I) editing is essential for the correction of pathogenic mutagenesis, as well as the regulation of gene expression and protein function in mammals. The significance of dsRNA A-to-I editing in disease development and occurrence is explored using inferential statistics and cluster analyses to investigate the enzymes involved in dsRNA editing that can catalyze editing sites across multiple biomarkers. This editing process, which occurs in coding or non-coding regions, has the potential to activate abnormal signalling pathways that contributes to disease pathogenesis. Notably, the ADAR family enzymes play a crucial role in initiating the editing process. ADAR1 is upregulated in most diseases as an oncogene during tumorigenesis, whereas ADAR2 typically acts as a tumour suppressor. Furthermore, this review also provides an overview of small molecular inhibitors that disrupt the expression of ADAR enzymes. These inhibitors not only counteract tumorigenicity but also alleviate autoimmune disorders, neurological neurodegenerative symptoms, and metabolic diseases associated with aberrant dsRNA A-to-I editing processes. In summary, this comprehensive review offers detailed insights into the involvement of dsRNA A-to-I editing in disease pathogenesis and highlights the potential therapeutic roles for related small molecular inhibitors. These scientific findings will undoubtedly contribute to the advancement of personalized medicine based on dsRNA A-to-I editing. |
| WOS关键词 | DYSCHROMATOSIS SYMMETRICA HEREDITARIA ; SEROTONIN 2C RECEPTOR ; AMYOTROPHIC-LATERAL-SCLEROSIS ; ADENOSINE-DEAMINASE ; GENE-EXPRESSION ; GLUR-B ; DIHYDROFOLATE-REDUCTASE ; HUMAN GLIOBLASTOMA ; VIRUS-INFECTION ; NONCODING RNAS |
| 资助项目 | National Natural Sciences Foundation of China[U20A20405] ; National Natural Sciences Foundation of China[23PJ1412300] ; Shanghai Pujiang Program |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001341217200001 |
| 出版者 | TAYLOR & FRANCIS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314041]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, Dean; Yang, Zizhao |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Dept Gen Surg, Peoples Hosp 7, Shanghai, Peoples R China 2.Chinese Acad Sci, NMPA Key Lab Qual Control Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Sch Pharmaceut Sci, Beijing, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai, Peoples R China 5.NMPA Key Lab Res & Evaluat Pharmacovigilance, Beijing, Peoples R China 6.Chinese Acad Med Sci & Peking Union Med Coll, Key Lab New Drug Discovery Based Class Chinese Med, Institue Med Plant Dev, Beijing, Peoples R China 7.Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing, Peoples R China 8.Chinese Acad Med Sci & Peking Union Med Coll, Beijing Key Lab Innovat Drug Discovery Tradit Chin, Inst Med Plant Dev, Beijing, Peoples R China 9.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Wanqing,Wu, Yufan,Zhang, Tong,et al. The role of dsRNA A-to-I editing catalyzed by ADAR family enzymes in the pathogeneses[J]. RNA BIOLOGY,2024,21(1):52-69. |
| APA | Liu, Wanqing,Wu, Yufan,Zhang, Tong,Sun, Xiaobo,Guo, Dean,&Yang, Zizhao.(2024).The role of dsRNA A-to-I editing catalyzed by ADAR family enzymes in the pathogeneses.RNA BIOLOGY,21(1),52-69. |
| MLA | Liu, Wanqing,et al."The role of dsRNA A-to-I editing catalyzed by ADAR family enzymes in the pathogeneses".RNA BIOLOGY 21.1(2024):52-69. |
入库方式： OAI收割
来源：上海药物研究所
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