Penijanacoranes A-F, Acorane-Type Sesquiterpenes from a Deep Sea-Derived Fungus Penicillium janthinellum SH0301
文献类型：期刊论文
| 作者 | Yang, Lu-Jia3,4; Lv, Ling3,4,5; Han, Zhuang2 ; Gu, Yu-Cheng1; Li, Xin3,4,5; Shao, Chang-Lun3,4,5; Liu, Zhi-Qing3,4,5; Wang, Chang-Yun3,4,5
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| 刊名 | CHINESE JOURNAL OF CHEMISTRY
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| 出版日期 | 2024-10-17 |
| 页码 | 7 |
| 关键词 | Natural products Acorane-type sesquiterpene Structure elucidation Deep-sea-derived fungus Penicillium janthinellum Biological activity Anti-inflammatory activity |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.202400836 |
| 英文摘要 | Six new acorane-type sesquiterpenes, named penijanacoranes A-F (1-6), as well as one known eudesmane sesquiterpenoid 1 alpha,6 beta,11-eudesm-triol (7) have been isolated from a deep-sea-derived fungus Penicillium janthinellum SH0301. Their structures and absolute configurations were established by the comprehensive spectroscopic analysis, TDDFT-ECD calculations, and X-ray diffraction. Penijanacorane A (1) was identified as a rare acorane-type sesquiterpene lactone featuring a novel 6/5/6 tricyclic system, while penijanacoranes E and F (5 and 6) represented undescribed examples of nor-acorane sesquiterpenes at C-1. Penijanacorane C (3) exhibited significant inhibitory activity against LPS-induced NO production in Raw264.7 macrophages with an IC50 value of 6.23 mu M, which was more potent than that of positive control dexamethasone (IC50 = 11.49 mu M). This study expanded the chemical diversity of acorane-type sesquiterpenoids and revealed that compound 3 was a potential molecule for anti-inflammatory agents. |
| WOS关键词 | METABOLITES ; ALKALOIDS ; ASSAY |
| 资助项目 | Major Project of Qingdao Marine Science and Technology Center[2022QNLM030003-1] ; Fundamental Research Funds for the Central Universities of China[202462006] ; Key Program of National Natural Science Foundation of China[41830535] ; Syngenta PhD Scholarship |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001338121300001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | Major Project of Qingdao Marine Science and Technology Center ; Fundamental Research Funds for the Central Universities of China ; Key Program of National Natural Science Foundation of China ; Syngenta PhD Scholarship |
| 源URL | [http://ir.idsse.ac.cn/handle/183446/11765]  |
| 专题 | 深海科学研究部_深海生物学研究室_海洋微生物宏基因组与分子进化研究组 |
| 通讯作者 | Liu, Zhi-Qing; Wang, Chang-Yun |
| 作者单位 | 1.Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England 2.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya 572000, Hainan, Peoples R China 3.Qingdao Marine Sci & Technol Ctr, Lab Marine Drugs & Bioprod, Qingdao 266237, Shandong, Peoples R China 4.Ocean Univ China, Inst Evolut & Marine Biodivers, Qingdao 266003, Shandong, Peoples R China 5.Ocean Univ China, Sch Med Pharm, MOE Key Lab Marine Drugs & Key Lab Evolut & Marine, Qingdao 266003, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Lu-Jia,Lv, Ling,Han, Zhuang,et al. Penijanacoranes A-F, Acorane-Type Sesquiterpenes from a Deep Sea-Derived Fungus Penicillium janthinellum SH0301[J]. CHINESE JOURNAL OF CHEMISTRY,2024:7. |
| APA | Yang, Lu-Jia.,Lv, Ling.,Han, Zhuang.,Gu, Yu-Cheng.,Li, Xin.,...&Wang, Chang-Yun.(2024).Penijanacoranes A-F, Acorane-Type Sesquiterpenes from a Deep Sea-Derived Fungus Penicillium janthinellum SH0301.CHINESE JOURNAL OF CHEMISTRY,7. |
| MLA | Yang, Lu-Jia,et al."Penijanacoranes A-F, Acorane-Type Sesquiterpenes from a Deep Sea-Derived Fungus Penicillium janthinellum SH0301".CHINESE JOURNAL OF CHEMISTRY (2024):7. |
入库方式： OAI收割
来源：深海科学与工程研究所
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