Study on the mechanism of echinacoside in preventing and treating hypoxic pulmonary hypertension based on proteomic analyses
文献类型：期刊论文
| 作者 | Gai, Xiangyun; Xia, Qingqing; Wang, Hongmai; Bi, Hongtao; Wang, Jinyu; Zhao, Yuefu |
| 刊名 | PHARMACOLOGY RESEARCH & PERSPECTIVES
 |
| 出版日期 | 2024 |
| 卷号 | 12期号:5 |
| 英文摘要 | Hypoxic pulmonary hypertension (HPH), a chronic condition affecting the cardiopulmonary system, has high mortality. Echinacoside (ECH) is a phenylethanoid glycoside, which is used to ameliorate pulmonary vascular remodeling and pulmonary vasoconstriction in rats. Accordingly, we aimed to explore the mechanism of ECH in preventing and treating HPH. Sprague Dawley rats were housed in a hypobaric hypoxia chamber for 28 days to obtain the HPH model. The experimental rats were randomly allocated into the following several groups: normoxia group, chronic hypoxia group, and ECH group. The therapeutic results of ECH (10, 20, and 40 mg/kg) showed that ECH reduced mPAP, Hb, Hct, and RVHI in HPH rats. Then this work employed label-free quantitative proteomic analysis, western blotting, and RT-PCR to investigate the mechanism by which ECH prevents HPH. The results found that in the chronic hypoxia group, the levels of ACSL1, COL6A1, COL4A2, COL1A1, and PC increased compared to the normoxia group. However, the opposite effect was observed in the chronic hypoxia group treated with ECH. The study indicates that the administration of ECH may slow the pathological progression of HPH by suppressing the inflammatory response, inhibiting smooth muscle cell proliferation, and minimizing the deposition of extracellular matrix.Timeline of prevention of hypoxic pulmonary hypertension by ECH (A) and treatment of hypoxic pulmonary hypertension by ECH (B).image |
| 源URL | [http://210.75.249.4/handle/363003/61934]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Gai, Xiangyun,Xia, Qingqing,Wang, Hongmai,et al. Study on the mechanism of echinacoside in preventing and treating hypoxic pulmonary hypertension based on proteomic analyses[J]. PHARMACOLOGY RESEARCH & PERSPECTIVES,2024,12(5). |
| APA | Gai, Xiangyun,Xia, Qingqing,Wang, Hongmai,Bi, Hongtao,Wang, Jinyu,&Zhao, Yuefu.(2024).Study on the mechanism of echinacoside in preventing and treating hypoxic pulmonary hypertension based on proteomic analyses.PHARMACOLOGY RESEARCH & PERSPECTIVES,12(5). |
| MLA | Gai, Xiangyun,et al."Study on the mechanism of echinacoside in preventing and treating hypoxic pulmonary hypertension based on proteomic analyses".PHARMACOLOGY RESEARCH & PERSPECTIVES 12.5(2024). |
入库方式： OAI收割
来源：西北高原生物研究所
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