Identification of Flavonoid from Wolfberry (Lycium barbarum) by Using Two-Step Chromatography and Bioactivity Exploration
文献类型：期刊论文
| 作者 | Liu, Chuang; Wang, Qilan ; Lei, Yuqing; Abd El-Aty, A. M.; Zhang, Gong
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| 刊名 | FOOD ANALYTICAL METHODS
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| 出版日期 | 2024 |
| 卷号 | 17期号:11 |
| 英文摘要 | Wolfberry (Lycium barbarum) has a nearly thousand-year history of medicinal and dietary use in China. The separation methodology of its bioactive components has always received much attention. In this study, the free radical scavenging activity of each fraction of wolfberry was assessed via a DPPH assay, after which a high-purity free radical inhibitor (rutin) was prepared directly from wolfberry via a two-step chromatographic process (MCI GEL (R) CHP20P and Sephadex (R) LH-20 columns). The potential molecular interactions between rutin and target proteins (SREBP-1, HMGCR, AKT1, ACC, AMPK, PPAR, LPL, TNF-alpha, and FAS) were explored using computer simulation; among these interactions, TNF-alpha exhibited a strong binding affinity for rutin (-9.49 kcal/mol). In conclusion, these findings provide deeper insights into the bioactivity of wolfberry and advance the study of quality control systems for wolfberry. Moreover, it also provides a potential chromatographic option for future functional food research. |
| 源URL | [http://210.75.249.4/handle/363003/61955]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Chuang,Wang, Qilan,Lei, Yuqing,et al. Identification of Flavonoid from Wolfberry (Lycium barbarum) by Using Two-Step Chromatography and Bioactivity Exploration[J]. FOOD ANALYTICAL METHODS,2024,17(11). |
| APA | Liu, Chuang,Wang, Qilan,Lei, Yuqing,Abd El-Aty, A. M.,&Zhang, Gong.(2024).Identification of Flavonoid from Wolfberry (Lycium barbarum) by Using Two-Step Chromatography and Bioactivity Exploration.FOOD ANALYTICAL METHODS,17(11). |
| MLA | Liu, Chuang,et al."Identification of Flavonoid from Wolfberry (Lycium barbarum) by Using Two-Step Chromatography and Bioactivity Exploration".FOOD ANALYTICAL METHODS 17.11(2024). |
入库方式： OAI收割
来源：西北高原生物研究所
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