Single-cell analysis identifies critical regulators of spermatogonial development and differentiation in cattle-yak bulls
文献类型：期刊论文
| 作者 | Zhang, Yi-Wen; Wu, Shi-Xin; Wang, Guo-Wen; Wan, Rui-Dong; Yang, Qi-En |
| 刊名 | JOURNAL OF DAIRY SCIENCE
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| 出版日期 | 2024 |
| 卷号 | 107期号:9 |
| 英文摘要 | Spermatogenesis is a continuous process in which functional sperm are produced through a series of mitotic and meiotic divisions and morphological changes in germ cells. The aberrant development and fate transitions of spermatogenic cells cause hybrid sterility in mammals. Cattle-yak, a hybrid animal between taurine cattle (Bos taurus) and yak (Bos grunniens), exhibits male-specific sterility due to spermatogenic failure. In the present study, we performed single-cell RNA sequencing analysis to identify differences in testicular cell composition and the developmental trajectory of spermatogenic cells between yak and cattle-yak. The composition and molecular signatures of spermatogonial subtypes were dramatically different between these 2 animals, and the expression of genes associated with stem cell maintenance, cell differentiation and meiotic entry was altered in cattle-yak, indicating the impairment of undifferentiated spermatogonial fate decisions. Cell communication analysis revealed that signaling within different spermatogenic cell subpopulations was weakened, and progenitor spermatogonia were unable to or delayed receiving and sending signals for ously, the communication between niche cells and germ expression profiles of transcriptome signatures of differspeciation in bovid species. |
| 源URL | [http://210.75.249.4/handle/363003/61974]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Yi-Wen,Wu, Shi-Xin,Wang, Guo-Wen,et al. Single-cell analysis identifies critical regulators of spermatogonial development and differentiation in cattle-yak bulls[J]. JOURNAL OF DAIRY SCIENCE,2024,107(9). |
| APA | Zhang, Yi-Wen,Wu, Shi-Xin,Wang, Guo-Wen,Wan, Rui-Dong,&Yang, Qi-En.(2024).Single-cell analysis identifies critical regulators of spermatogonial development and differentiation in cattle-yak bulls.JOURNAL OF DAIRY SCIENCE,107(9). |
| MLA | Zhang, Yi-Wen,et al."Single-cell analysis identifies critical regulators of spermatogonial development and differentiation in cattle-yak bulls".JOURNAL OF DAIRY SCIENCE 107.9(2024). |
入库方式： OAI收割
来源：西北高原生物研究所
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