Gut microbiome and antibiotic resistance genes in plateau model animal (Ochotona curzoniae) exhibit a relative stability under cold stress
文献类型：期刊论文
| 作者 | Mu, Xianxian; Shi, Shunqin; Hu, Xueqian; Gan, Xueying; Han, Qian; Yu, Qiaoling; Qu, Jiapeng ; Li, Huan
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| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
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| 出版日期 | 2024 |
| 卷号 | 478 |
| 英文摘要 | Antibiotic resistance genes (ARGs) carried by gut pathogens may pose a threat to the host and ecological environment. However, few studies focus on the effects of cold stress on intestinal bacteria and ARGs in plateau animals. Here, we used 16S rRNA gene sequencing and gene chip technique to explore the difference of gut microbes and ARGs in plateau pika under 4 degrees C and 25 degrees C. The results showed that tetracycline and aminoglycoside resistance genes were the dominant ARGs in pika intestine. Seven kinds of high-risk ARGs (aadA-01, aadA-02, ermB, floR, mphA-01, mphA-02, tetM-02) existed in pika's intestine, and cold had no significant effect on the composition and structure of pika's intestinal ARGs. The dominant phyla in pika intestine were Bacteroidetes and Firmicutes. Cold influenced 0.47% of pika intestinal bacteria in OTU level, while most other bacteria had no significant change. The diversity and community assembly of intestinal bacteria in pika remained relatively stable under cold conditions, while low temperature decreased gut microbial network complexity. In addition, low temperature led to the enrichment of glycine biosynthesis and metabolism-related pathways. Moreover, the correlation analysis showed that eight opportunistic pathogens (such as Clostridium, , Staphylococcus, , Streptococcus, , etc.) detected in pika intestine might be potential hosts of ARGs. |
| 源URL | [http://210.75.249.4/handle/363003/61978]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Mu, Xianxian,Shi, Shunqin,Hu, Xueqian,et al. Gut microbiome and antibiotic resistance genes in plateau model animal (Ochotona curzoniae) exhibit a relative stability under cold stress[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,478. |
| APA | Mu, Xianxian.,Shi, Shunqin.,Hu, Xueqian.,Gan, Xueying.,Han, Qian.,...&Li, Huan.(2024).Gut microbiome and antibiotic resistance genes in plateau model animal (Ochotona curzoniae) exhibit a relative stability under cold stress.JOURNAL OF HAZARDOUS MATERIALS,478. |
| MLA | Mu, Xianxian,et al."Gut microbiome and antibiotic resistance genes in plateau model animal (Ochotona curzoniae) exhibit a relative stability under cold stress".JOURNAL OF HAZARDOUS MATERIALS 478(2024). |
入库方式： OAI收割
来源：西北高原生物研究所
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