Genome-Wide Association Analyses and Population Verification Highlight the Potential Genetic Basis of Horned Morphology during Polled Selection in Tibetan Sheep
文献类型：期刊论文
| 作者 | Tian, Dehong; Zhang, Zian; Huang, Bin; Han, Buying; Li, Xue; Zhao, Kai
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| 刊名 | ANIMALS
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| 出版日期 | 2024 |
| 卷号 | 14期号:15 |
| 英文摘要 | Simple Summary The horned type of sheep, including the polled phenotype and scurs phenotype, emerged during the process of artificial domestication. Sheep serve as an optimal animal model for investigating the correlation between quality and quantity traits of horns, as well as the multi-gene regulatory mechanism underlying these traits. While significant progress has been made in understanding the effects of natural selection and sex selection on horn phenotypes, there is limited research on polymorphisms resulting from artificial selection. Through genome-wide association analysis, this study reveals the genetic mapping of horn phenotypes, polled genes, and superior haplotypes to provide valuable insights into studying the genetic mechanisms governing horn traits and other specific characteristics in ruminants while also laying a foundation for breeding.Abstract The types and morphology of sheep horns have been extensively researched, yet the genetic foundation underlying the emergence of diverse horn characteristics during the breeding of polled Tibetan sheep has remained elusive. Genome-wide association analysis (GWAS) was performed on 103 subtypes (normal large horn, scurs, and polled) differentiated from G2 (offspring (G2) of parent (G1) of polled) of the polled core herd. Six single nucleotide polymorphisms (SNPs) located on chromosome 10 of the relaxin family peptide receptor 2 (RXFP2) gene exhibited positive correlations with horn length, horn base circumference, and horn base interval. Furthermore, in genotyping 382 G2 individuals, significant variations were observed for each specific horn type. Three additional mutations were identified near the target SNP upstream of the amplification product. Finally, the RXFP2-specific haplotype associated with the horned trait effectively maintained horn length, horn base circumference, and horn base interval in Tibetan sheep, as confirmed by population validation of nine loci in a sample size of 1125 individuals. The present study offers novel insights into the genetic differentiation of the horned type during improvement breeding and evolution, thereby establishing a robust theoretical foundation for polled Tibetan sheep breeding and providing valuable guidance for practical production. |
| 源URL | [http://210.75.249.4/handle/363003/61982]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Tian, Dehong,Zhang, Zian,Huang, Bin,et al. Genome-Wide Association Analyses and Population Verification Highlight the Potential Genetic Basis of Horned Morphology during Polled Selection in Tibetan Sheep[J]. ANIMALS,2024,14(15). |
| APA | Tian, Dehong,Zhang, Zian,Huang, Bin,Han, Buying,Li, Xue,&Zhao, Kai.(2024).Genome-Wide Association Analyses and Population Verification Highlight the Potential Genetic Basis of Horned Morphology during Polled Selection in Tibetan Sheep.ANIMALS,14(15). |
| MLA | Tian, Dehong,et al."Genome-Wide Association Analyses and Population Verification Highlight the Potential Genetic Basis of Horned Morphology during Polled Selection in Tibetan Sheep".ANIMALS 14.15(2024). |
入库方式： OAI收割
来源：西北高原生物研究所
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