Exploratory studies of the antidepressant effect of Cordyceps sinensis polysaccharide and its potential mechanism
文献类型：期刊论文
| 作者 | Zhang, Xingfang; Qiao, Yajun; Li, Guoqiang; Rong, Lin; Liang, Xinxin; Wang, Qiannan; Liu, Yi; Pi, Li; Wei, Lixin ; Bi, Hongtao
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2024 |
| 卷号 | 277 |
| 英文摘要 | Cordyceps sinensis, a traditionally prized medicinal fungus, contains polysaccharides as one of its main bioactive constituents, known for their significant immunomodulatory properties. In this study, we systematically investigated the composition and structure of Cordyceps sinensis polysaccharide, followed by an evaluation of its therapeutic effect on depression using a chronic restraint stress-induced depression model. The polysaccharide CSWP-2, extracted via hot water, precipitated with ethanol, and purified using DEAE-cellulose column chromatography from Cordyceps sinensis, is primarily composed of glucose, mannose, and galactose, with alpha-1,4-Dglucan as its major structural component. Behavioral tests, immunological profiling, metabolomics, and gut microbiota analyses indicated a notable ameliorative effect of CSWP-2 on depressive-like symptoms in mice. Furthermore, the action of CSWP-2 may be attributed to the modulation of the gut microbiome's abundance and its metabolic impacts, thereby transmitting signals to the host immune system and exerting immunomodulatory activity, ultimately contributing to its antidepressant effects. |
| 源URL | [http://210.75.249.4/handle/363003/61983]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Xingfang,Qiao, Yajun,Li, Guoqiang,et al. Exploratory studies of the antidepressant effect of Cordyceps sinensis polysaccharide and its potential mechanism[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,277. |
| APA | Zhang, Xingfang.,Qiao, Yajun.,Li, Guoqiang.,Rong, Lin.,Liang, Xinxin.,...&Bi, Hongtao.(2024).Exploratory studies of the antidepressant effect of Cordyceps sinensis polysaccharide and its potential mechanism.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,277. |
| MLA | Zhang, Xingfang,et al."Exploratory studies of the antidepressant effect of Cordyceps sinensis polysaccharide and its potential mechanism".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 277(2024). |
入库方式： OAI收割
来源：西北高原生物研究所
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