Genome-wide association studies of body size traits in Tibetan sheep
文献类型：期刊论文
| 作者 | Liu, Dehui; Li, Xue; Wang, Lei; Pei, Quanbang; Zhao, Jincai; Sun, De; Ren, Qianben; Tian, Dehong; Han, Buying; Jiang, Hanjing |
| 刊名 | BMC GENOMICS
 |
| 出版日期 | 2024 |
| 卷号 | 25期号:1 |
| 英文摘要 | BackgroundElucidating the genetic variation underlying phenotypic diversity will facilitate improving production performance in livestock species. The Tibetan sheep breed in China holds significant historical importance, serving as a fundamental pillar of Qinghai's animal husbandry sector. The Plateau-type Tibetan sheep, comprising 90% of the province's population, are characterized by their tall stature and serve as the primary breed among Tibetan sheep. In contrast, Zhashijia sheep exhibit larger size and superior meat quality. These two species provide an excellent model for elucidating the genetic basis of body size variation. Therefore, this study aims to conduct a comprehensive genome-wide association study on these two Tibetan sheep breeds to identify single nucleotide polymorphism loci and regulatory genes that influence body size traits in Tibetan sheep.ResultIn this study, the phenotypic traits of body weight, body length, body height, chest circumference, chest depth, chest width, waist angle width, and pipe circumference were evaluated in two Tibetan sheep breeds: Plateau-type sheep and Zhashijia Tibetan sheep. Whole genome sequencing generated 48,215,130 high-quality SNPs for genome-wide association study. Four methods were applied and identified 623 SNPs significantly associated with body size traits. The significantly associated single nucleotide polymorphisms identified in this study are located near or within 111 candidate genes. These genes exhibit enrichment in the cAMP and Rap1 signaling pathways, significantly affecting animal growth, and body size. Specifically, the following genes were associated: ASAP1, CDK6, FRYL, NAV2, PTPRM, GPC6, PTPRG, KANK1, NTRK2 and ADCY8.ConclusionBy genome-wide association study, we identified 16 SNPs and 10 candidate genes associated with body size traits in Tibetan sheep, which hold potential for application in genomic selection breeding programs in sheep. Identifying these candidate genes will establish a solid foundation for applying molecular marker-assisted selection in sheep breeding and improve our understanding of body size control in farmed animals. |
| 源URL | [http://210.75.249.4/handle/363003/61984]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Dehui,Li, Xue,Wang, Lei,et al. Genome-wide association studies of body size traits in Tibetan sheep[J]. BMC GENOMICS,2024,25(1). |
| APA | Liu, Dehui.,Li, Xue.,Wang, Lei.,Pei, Quanbang.,Zhao, Jincai.,...&Zhao, Kai.(2024).Genome-wide association studies of body size traits in Tibetan sheep.BMC GENOMICS,25(1). |
| MLA | Liu, Dehui,et al."Genome-wide association studies of body size traits in Tibetan sheep".BMC GENOMICS 25.1(2024). |
入库方式： OAI收割
来源：西北高原生物研究所
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