Transgenerational Inheritance Effects of Copper Oxide Nanoparticles (CuONPs) Induced Asthenospermia and Infertility via Gamete H3K9me3 Insufficiency Pathway in Mice
文献类型：期刊论文
| 作者 | Shaoyong, Weike; Wang, Wusu; Pan, Bo; Liu, Rui; Yin, Lin; Wangjie, Reshouyang; Tian, Haolun; Wang, Yizhen; Jin, Mingliang |
| 刊名 | ACS NANO
 |
| 出版日期 | 2024 |
| 卷号 | 18期号:31 |
| 英文摘要 | The widespread use of colloidal copper oxide nanoparticles (CuONPs) poses substantial health risks to humans. CuONPs can penetrate the blood-testis barrier and induce spermatocide, and the understanding of the adverse effects of asthenospermia on spermatogenesis, embryonic development, and transgenerational inheritance is limited. In this study, male mice were orally administered different doses of CuONPs via continuous exposure for one spermatozoon development period (35 days) and then exposed without CuONPs for another 35 days. The CuONPs that accumulated in the testes induced oxidative stress (OS), affected the progress of spermatogenesis and sperm capacitation, and compromised epigenetic modifications, resulting in asthenospermia and embryonic development anomalies in male offspring. In a mechanism, CuONP exposure impaired the self-renewal and differentiation of spermatogonial stem cells (SSCs) via the GDNF/PI3K/AKT signaling pathway under OS. Importantly, CuONP exposure was found to potentially lower H3K9me3 levels in paternal sperm, which would further transgenerational transmission and interfere with sperm mitochondrial energy metabolism and motility, leading to asthenospermia and subfertility in the offspring. Collectively, these data reveal a molecular mechanism by which CuONP exposure disturbs H3K9me3 levels via the OS pathway, which further mediates the asthenospermic effects of reproductive failure by interfering with mitochondrial arrangement and formation in the next generation. |
| 源URL | [http://210.75.249.4/handle/363003/61985]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Shaoyong, Weike,Wang, Wusu,Pan, Bo,et al. Transgenerational Inheritance Effects of Copper Oxide Nanoparticles (CuONPs) Induced Asthenospermia and Infertility via Gamete H3K9me3 Insufficiency Pathway in Mice[J]. ACS NANO,2024,18(31). |
| APA | Shaoyong, Weike.,Wang, Wusu.,Pan, Bo.,Liu, Rui.,Yin, Lin.,...&Jin, Mingliang.(2024).Transgenerational Inheritance Effects of Copper Oxide Nanoparticles (CuONPs) Induced Asthenospermia and Infertility via Gamete H3K9me3 Insufficiency Pathway in Mice.ACS NANO,18(31). |
| MLA | Shaoyong, Weike,et al."Transgenerational Inheritance Effects of Copper Oxide Nanoparticles (CuONPs) Induced Asthenospermia and Infertility via Gamete H3K9me3 Insufficiency Pathway in Mice".ACS NANO 18.31(2024). |
入库方式： OAI收割
来源：西北高原生物研究所
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