Optimization of subcritical water extraction, UPLC-triple-TOF-MS/MS analysis, antioxidant and α-glucosidase inhibitory activities of anthocyanins from Nitraria sibirica Pall. fruits
文献类型：期刊论文
| 作者 | Ren, Lichengcheng; Dong, Qi; Liu, Zhenhua; Wang, Yue; Tan, Nixia; Wang, Honglun ; Hu, Na
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| 刊名 | FOOD CHEMISTRY-X
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| 出版日期 | 2024 |
| 卷号 | 23 |
| 英文摘要 | This study aimed to optimize subcritical water extraction process, characterize chemical composition and investigate the biological activities of Nitraria sibirica Pall. (NSP) anthocyanin. Overall, the optimization was achieved under following conditions: extraction temperature 140 degrees C, extraction time 45 min and flow rate 7 mL/ min with the extraction yield of 1.075 mg/g. 3 cyanidin, 3 petunidin, 1 delphinidin and 1 pelargonidin compounds were identified in the anthocyanic extract from NSP via UPLC-Triple-TOF-MS/MS. NSP anthocyanin exhibited better DPPH free-radical scavenging activity than ascorbic acid. It displayed superior alpha-glucosidase inhibition activity, which was similar to 14 times higher than that of acarbose. Moreover, enzyme kinetics results indicated that NSP anthocyanin behaved as a reversible, mixed-type inhibitor. Molecular docking and molecular dynamics simulation results revealed that NSP anthocyanin interacted with alpha-glucosidase mainly via van der Waals forces, hydrogen bond and possessed fairly stable configuration. Therefore, NSP anthocyanin is a promising alpha-glucosidase inhibitor for diabetes mellitus. |
| 源URL | [http://210.75.249.4/handle/363003/61993]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Ren, Lichengcheng,Dong, Qi,Liu, Zhenhua,et al. Optimization of subcritical water extraction, UPLC-triple-TOF-MS/MS analysis, antioxidant and α-glucosidase inhibitory activities of anthocyanins from Nitraria sibirica Pall. fruits[J]. FOOD CHEMISTRY-X,2024,23. |
| APA | Ren, Lichengcheng.,Dong, Qi.,Liu, Zhenhua.,Wang, Yue.,Tan, Nixia.,...&Hu, Na.(2024).Optimization of subcritical water extraction, UPLC-triple-TOF-MS/MS analysis, antioxidant and α-glucosidase inhibitory activities of anthocyanins from Nitraria sibirica Pall. fruits.FOOD CHEMISTRY-X,23. |
| MLA | Ren, Lichengcheng,et al."Optimization of subcritical water extraction, UPLC-triple-TOF-MS/MS analysis, antioxidant and α-glucosidase inhibitory activities of anthocyanins from Nitraria sibirica Pall. fruits".FOOD CHEMISTRY-X 23(2024). |
入库方式： OAI收割
来源：西北高原生物研究所
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