Rhodiosin from Rhodiola crenulata effectively alleviate postprandial hyperglycemia by inhibiting both the activity and production of α- glucosidase
文献类型：期刊论文
| 作者 | Wang, Luya; Wu, Li; Li, Jiaxin; Cailang, Banma; Zhao, Xiaohui; Yue, Huilan |
| 刊名 | PHYTOMEDICINE
 |
| 出版日期 | 2024 |
| 卷号 | 132 |
| 英文摘要 | Background: Effective control of postprandial blood glucose (PBG) level is essential for the prevention and treatment of diabetes and its complications. Several flavonoids have attracted much attention due to their significant PBG-lowering effects. However, there is still a certain gap in the in vivo hypoglycemic activity of most flavonoids compared to first -line drugs available on the market, and are still lack of the PBG-lowering effects of 8hydroxyflavones and their structure -activity relationship. Purpose: Evaluate hypoglycemic effects of 8-hydroxyflavones from Rhodiola crenulata in vitro and in vivo, especially comparatively analyze the relationship between hypoglycemic effects and flavonoid configuration and reveal the possible mechanism of 8-hydroxyflavones in lowering hyperglycemia. Methods: Starch, maltose, sucrose, and glucose tolerance tests in both diabetic and normal mice were used to evaluate and compare the hypoglycemic effects of 8-hydroxyflavones rhodiosin (RHS), rhodionin (RHN), and herbacetin (HBT). Molecular docking, enzyme kinetics, and immunofluorescence analysis were used to research the possible hypoglycemic mechanisms of 8-hydroxyflavones. Results: RHS (5 and 10 mg/kg) could efficiently decrease PBG levels in both normal and diabetes mice. Moreover, RHS, RHN, and HBT all had significant PBG-lowering effects in transgenic diabetes mice, and the effects were equivalent to or stronger than acarbose. Further mechanism research indicated that 8-hydroxyflavones achieved PBG-lowering effects by inhibiting both the activity and production of glycosidase. Notably, we have innovatively discovered that inhibiting the expression of glycosidases rather than just their activities may be a new target for hypoglycemic drugs. Conclusion: We have firstly comprehensively and systematically clarified PBG-lowering effects of 8-hydroxyflavones from Rhodiola crenulata , and revealed their structure -activity relationships and hypoglycemic mechanisms. The study demonstrated that the substitution of 8-hydroxy groups in flavonoids could significantly enhance their hypoglycemic effects, which were equivalent to or stronger than commercially available drug acarbose. 8-Hydroxyflavones could be used as therapeutic or health drugs with significant potential to reduce postprandial hyperglycemia. |
| 源URL | [http://210.75.249.4/handle/363003/62005]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Luya,Wu, Li,Li, Jiaxin,et al. Rhodiosin from Rhodiola crenulata effectively alleviate postprandial hyperglycemia by inhibiting both the activity and production of α- glucosidase[J]. PHYTOMEDICINE,2024,132. |
| APA | Wang, Luya,Wu, Li,Li, Jiaxin,Cailang, Banma,Zhao, Xiaohui,&Yue, Huilan.(2024).Rhodiosin from Rhodiola crenulata effectively alleviate postprandial hyperglycemia by inhibiting both the activity and production of α- glucosidase.PHYTOMEDICINE,132. |
| MLA | Wang, Luya,et al."Rhodiosin from Rhodiola crenulata effectively alleviate postprandial hyperglycemia by inhibiting both the activity and production of α- glucosidase".PHYTOMEDICINE 132(2024). |
入库方式： OAI收割
来源：西北高原生物研究所
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