Clioquinol rescues yeast cells from Aβ42 toxicity via the inhibition of oxidative damage
文献类型：期刊论文
| 作者 | Zheng, Qiaoqiao; Zhu, Hongzheng; Lv, Chunyi; Zhu, Ziting; Cui, Hanyue; Fan, Zheyu; Sun, Jing; Huang, Zhiwei; Shi, Ping |
| 刊名 | BIOTECHNOLOGY JOURNAL
 |
| 出版日期 | 2024 |
| 卷号 | 19期号:6 |
| 英文摘要 | Alzheimer's disease (AD), the most common form of dementia, has gotten considerable attention. Previous studies have demonstrated that clioquinol (CQ) as a metal chelator is a potential drug for the treatment of AD. However, the mode of action of CQ in AD is still unclear. In our study, the antioxidant effects of CQ on yeast cells expressing A beta 42 were investigated. We found that CQ could reduce A beta 42 toxicity by alleviating reactive oxygen species (ROS) generation and lipid peroxidation level in yeast cells. These alterations were mainly attributable to the increased reduced glutathione (GSH) content and independent of activities of superoxide dismutase (SOD) and/or catalase (CAT). CQ could affect antioxidant enzyme activity by altering the transcription level of related genes. Interestingly, it was noted for the first time that CQ could combine with antioxidant enzymes to reduce their enzymatic activities by molecular docking and circular dichroism spectroscopy. In addition, CQ restored A beta 42-mediated disruption of GSH homeostasis via regulating YAP1 expression to protect cells against oxidative stress. Our findings not only improve the current understanding of the mechanism of CQ as a potential drug for AD treatment but also provide ideas for subsequent drug research and development. |
| 源URL | [http://210.75.249.4/handle/363003/62023]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Zheng, Qiaoqiao,Zhu, Hongzheng,Lv, Chunyi,et al. Clioquinol rescues yeast cells from Aβ42 toxicity via the inhibition of oxidative damage[J]. BIOTECHNOLOGY JOURNAL,2024,19(6). |
| APA | Zheng, Qiaoqiao.,Zhu, Hongzheng.,Lv, Chunyi.,Zhu, Ziting.,Cui, Hanyue.,...&Shi, Ping.(2024).Clioquinol rescues yeast cells from Aβ42 toxicity via the inhibition of oxidative damage.BIOTECHNOLOGY JOURNAL,19(6). |
| MLA | Zheng, Qiaoqiao,et al."Clioquinol rescues yeast cells from Aβ42 toxicity via the inhibition of oxidative damage".BIOTECHNOLOGY JOURNAL 19.6(2024). |
入库方式： OAI收割
来源：西北高原生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。